Professor


 

Jiashing Yu Associate Professor

游佳欣 副教授

phone:(02)3366-9477
fax:(02)2362-3040

email: jiayu

office:工綜479

 

Lab Info

Biomedical and Tissue Engineering Lab

工綜419

(02)3366-9605

Education Background

National Taiwan University          Chemical Engineering     B.S.        2003

UC Berkeley and UC San Francisco                   Bioengineering       Ph.D.        2008

UCSF Cardiovascular Research Institute and
California Institute of Regenerative Medicine                  Post doc.     2010


Research Topic

Cardiac Tissue Engineering
Tissue engineering approach (cell, matrix, cytokine) to repair damaged cardiac tissue in vitro and in vivo.


 

Costumed-design of Biomaterials

1.Surface modification of biomaterials to enhance cell and extracellular matrix (ECM) interaction
2.Antibody and peptides conjugated nanoparticles as biosensors and drug delivery vehicles


 

Stem Cell Therapies in Cardiac Repair
Characterization of mesenchymal stem cells (MSCs), cardiac progenitor cells and guided-differentiation of embryonic stem cell (ESCs) to cardiac specific cells to repair myocardial infarction


Recent Research Topic

Cell encapsulation and culture in alginate-based microspheres using air pressure driven device

Controlled drug release of microcapsules made of Biological derived materials

Validation of 3D culture system and its application in hASCs(human adipose-derived stem cell) expansion.

Biological microbubbles for Cardiomyocyte


Honor

 
The Representative Publication Recent 5-years Publication

1. Yu J, Christman KL, Chin E, Sievers RE, Lee RJ. Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy. Journal of Thoracic and Cardiovascular Surgery. Jan.;137(1):180-7. (2009)(SCI)

2. Yu J, Gu Y, Du KT. Mihardja S, Sievers RE. Lee RJ. The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model. Biomaterials. Feb;30(5):751-6. (2009)(SCI,EI)

3. Yu J, Du KT, Fang Q, Gu Y, Mihardja SS, Sievers RE, Wu JC, Lee RJ. The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat. Biomaterials. Sep;31(27):7012-20. (2010) (SCI,EI)

4. Mihardja SS, Yu J, Lee RJ. “Extracellular matrix-derived peptides and myocardial repair.” Cell Adhesion & Migration, volume 5, issue 2 (2010)

5. Wang PY, Yu J, WB Tsai. Modulation of Alignment, Elongation and Contraction of Cardiomyocytes through Combination of Nanotopography and Rigidity of Substrates. Acta Biomaterialia. May;(7): 3285–3293.(2011)(SCI)

6. Wu JT, Huang CH, Liang WC, Wu YL, Yu J, Chen HY. Reactive polymer coatings: a general route to thiol-ene and thiol-yne click reactions. Macromol Rapid Commun. 2012 May 29;33(10):922-7. (SCI)

7. Liao YC, Ma YT, Huang CH, Yu J, Hsiao HM. Rigidity Guided Cell Attachment on Inkjet-Printed Patterns. ACS Appl Mater Interfaces. 2012 Jun 28 (SCI)

8. Wang PY, Li WT, Yu J, Tsai WB. Modulation of osteogenic, adipogenic and myogenic differentiation of mesenchymal stem cells by submicron grooved topography. J Mater Sci Mater Med. 2012 Aug 19. (SCI)

9. Tsai MY, Lin CY, Huang CH, Gu JA, Huang ST, Yu J, Chen HY. Vapor-based synthesis of maleimide-functionalized coating for biointerface engineering.Chem Commun (Camb). 2012 Oct 4. (SCI)

10. Huang CC, Wu MD, Liang D, Yu J, Shih PJ, Shih WP. Fabrication and Application of Iron(III)-Oxide Nanoparticle/Polydimethylsiloxane Composite Cone in Microfluidic Channels. J Nanomaterials. Volume 2012 (2012), Article ID 986454 (SCI)

11. Chiu PJ, Mei JC, Huang YC, Yu J. Monolayer microbubbles fabricated by microfluidic device for Keratocyes observation. J Microelectronic Engineering. NanoBiotechnologies and NanoBiosystems .2012 Dec. special issue (SCI)

12. Liao MY, Wu CH, Lai PS, Yu J, Lin HP, Liu TM, Huang CC. Surface States Mediated NIR Two-Photon Fluorescence of Iron Ox-ides for Nonlinear Optical Microscopy. Adv. Funct. Mater., 2012 Nov, 10.(SCI)

13. Liao YT, Wu CW, Yu J*. Synthesis of mesoporous silica nanoparticle-encapsulated alginate microparticles for sustained release and targeting therapy. Journal of Biomedical Material Research B: Applied Biomaterials.2013 July (SCI)

14. Mihardja SS, Gonzales JA, Gao D, Sievers RE, Fang Q, Stillson CA, Yu J, Peng M, Lee RJ*. The effect of a peptide-modified thermo-reversible methylcellulose on wound healing and LV function in a chronic myocardial infarction rodent model. Biomaterials. 2013 Jul (SCI)

15. Yu J, Sievers RE, Lee RJ*. Beneficial effects of Scaffold delivered SDF-1alpha Protein in a Chronic Rat MI Model. Journal of Medical and Biological Engineering. 2013 Aug (SCI)

16. Yu J, Wu PC, Huang CH, Yang CY and Cheng CM. High-throughput physically based approach for mammalian cell encapsulation. Applied Physics Letters .2013 Oct 10 (SCI)

17. Tsai MY, Cheng YC, Lin TJ, Hsu, TJ, Hsu YC, Lin CY, Yuan RH, Yu J, Teng MS, Hirtz M, Chen HC, Chang CH, Cheng HY. Vapor-Based Multicomponent Coatings for Antifouling and Biofunctional Synergic Modifications. Advanced Functional Materials. 2014,DOI: 10.1002/adfm.201303050

18. Yu J, Tu YK, Tang YB, Cheng NC*. Stemness and transdifferentiation of adipose-derived stem cells using L-ascorbic acid 2-phosphate-induced cell sheet formation. Biomaterials. (Accepted) (SCI)

19. Yu J, Lee AR, Lin WH, Lin CW, Wu YK, Tsai WB*. Electrospun PLGA fibers incorporated with functionalized biomolecules for cardiac tissue engineering. Tissue Engineering Part A. (Accepted) (SCI)

20. CY Lin, YK Wu, NC Cheng and Yu J*. Maintenance of hASC Differentiation Capabilities by 3D Culture. Biotechnology Letters. (Accepted) (SCI)