Research Topic

Cardiac Tissue Engineering
Tissue engineering approach (cell, matrix, cytokine) to repair damaged cardiac tissue in vitro and in vivo.

Costumed-design of Biomaterials

1.Surface modification of biomaterials to enhance cell and extracellular matrix (ECM) interaction
2.Antibody and peptides conjugated nanoparticles as biosensors and drug delivery vehicles

Stem Cell Therapies in Cardiac Repair
Characterization of mesenchymal stem cells (MSCs), cardiac progenitor cells and guided-differentiation of embryonic stem cell (ESCs) to cardiac specific cells to repair myocardial infarction

Recent Research Topic

Cell encapsulation and culture in alginate-based microspheres using air pressure driven device

Controlled drug release of microcapsules made of Biological derived materials

Validation of 3D culture system and its application in hASCs(human adipose-derived stem cell) expansion.

Biological microbubbles for Cardiomyocyte

Honor

The Representative Publication Recent 5-years Publication

1. Gu Y, Yu J, Lum LG, Lee RJ. Tissue engineering and stem cell therapy for myocardial repair. Front Biosci. 2007 Sep 1; 12: 5157-65. (2007) (SCI)

2. Yu J, Christman KL, Chin E, Sievers RE, Lee RJ. Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy. Journal of Thoracic and Cardiovascular Surgery. Jan.;137(1):180-7. (2009)(SCI)

3. Yu J, Gu Y, Du KT. Mihardja S, Sievers RE. Lee RJ. The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model. Biomaterials. Feb;30(5):751-6. (2009)(SCI,EI)

4. Yu J, Du KT, Fang Q, Gu Y, Mihardja SS, Sievers RE, Wu JC, Lee RJ. The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat. Biomaterials. Sep;31(27):7012-20. (2010) (SCI,EI)

5. Mihardja SS, Yu J, Lee RJ. “Extracellular matrix-derived peptides and myocardial repair.” Cell Adhesion & Migration, volume 5, issue 2 (2010)

6. Wang PY, Yu J, WB Tsai. Modulation of Alignment, Elongation and Contraction of Cardiomyocytes through Combination of Nanotopography and Rigidity of Substrates. Acta Biomaterialia. May;(7): 3285–3293.(2011)(SCI)