Hsien-Yeh Chen Associate Professor

陳賢燁 副教授


email: hsychen



Lab Info

Biointerface Engineering Lab



Education Background

B.S. Ch.E.   National Taiwan University    1999
M.S. Ch.E.   University of Michigan       2004
Ph.D. Ch.E.  University of Michigan       2008

Research Topic

Vapor-Based Functional Polymer Coating
Functionalized poly(p-xylylenes) constitute an versatile class of Reactive Polymers that can be prepared in a solventless process via chemical vapor deposition (CVD) polymerization. The resulting ultra-thin coatings are typically pinhole-free and can be conformally deposited onto a wide range of substrates and materials. More importantly, equipped functional groups can serve as anchoring sites for tailoring of biointerface properties via immobilization of biomolecules. These Reactive Polymers represent a powerful tool of surface engineering for applications in biotechnology.


Biointerface Engineering

Latest advancements in biomaterials aim to control biological responses. The critical criteria for designing biointerfaces include controlled properties of biomolecules, non-fouling, compatibility with microfabrication, accessible within microgeometries, applicability on 3-D objects, defined microstructures, cell/surface responses, biodegradability, and the ability to create surface gradient.  Our group has focused on engineering of biointerface by using vapor-based reactive polymers. Recent works include: 1. Non-fouling modification 2. Chemical and topographical modification for directed biological response 3. Surface modification of microfluidic system.

Recent Research Topic


The Representative Publication Recent 5-years Publication

1. Yaseen Elkasabi, Himabindu Nandivada, Hsien-Yeh Chen, Srijanani Bhaskar, John D'Arcy, Lidija Bondarenko, and Joerg Lahann “Partially Fluorinated Poly-p-xylylenes Synthesized by CVD Polymerization,” Chemical Vapor Deposition 15, 142-149 (2009). (SCI, EI)

2. Wei-Wen Hu, Yaseen Elkasabi, Hsien-Yeh Chen, Ying Zhang, Joerg Lahann, Scott J. Hollister, and Paul H. Krebsbach “The use of reactive polymer coatings to facilitate gene delivery from poly ([var epsilon]-caprolactone) scaffolds,” Biomaterials 30, 5785-5792 (2009). (SCI, EI)

3. John P. Seymour, Yaseen M. Elkasabi, Hsien-Yeh Chen, Joerg Lahann, and Daryl R. Kipke “The insulation performance of reactive parylene films in implantable electronic devices,” Biomaterials 30, 6158-6167 (2009). (SCI, EI)

4. Hsien-Yeh Chen, and Joerg Lahann “Surface Patterning Strategies for Microfluidic Applications based on Functionalized Poly-p-xylylenes,” Bioanalysis, 10, 1717-1728 (2010). (SCI, EI)

5. Hsien-Yeh Chen, Michael Hirtz, Xiaopei Deng, Thomas Laue, Harald Fuchs, and Joerg Lahann “Substrate-Independent Dip-Pen Nanolithography Based on Reactive Coatings, “ Journal of the American Chemical Society, 132, 18023-18025 (2010). (SCI, EI)

6. Hsien-Yeh Chen, and Joerg Lahann “Designable Biointerfaces Using Vapor-Based Reactive Polymers,” Langmuir, 27, 34-48 (2011). (SCI, EI)

7. Jyun-Ting Wu, Chi-Hui Huang, Wei-Chieh Liang, Yen-Lin Wu, Jiashing Yu, Hsien-Yeh Chen “Reactive Polymer Coatings: A General Route to Thiol-ene and Thiol-yne Click Reactions,” Macromolecular Rapid Communications, 33(10), 922-927 (2012). (SCI, EI)

8. Mu-Gi Wu, Hung-Lun Hsu, Kai-Wen Hsiao, Chih-Chen Hsieh, and Hsien-Yeh Chen “Vapor-Deposited Parylene Photoresist: A Multipotent Approach Toward Chemically and Topographically Defined Biointerfaces,”Langmuir, 28, 14313-14322 (2012). (SCI, EI)

9. Meng-Yu Tsai, Ching-Yu Lin, Chi-Hui Huang, Jiun-An Gu, Sheng-Tung Huang, Jiashing Yu and Hsien-Yeh Chen “Vapor-Based Synthesis of Maleimide-Functionalized Coating for Biointerface Engineering,” Chemical Communications, 48, 10969-10971 (2012). (SCI, EI)

10. Tsung-Yen Tsou, Hsien-Yeh Chen, Chih-Chen Hsieh* “Bihydrogel particles as free-standing mechanical pH microsensors,” Applied Physics Letters, 102(3), 031901-031904 (2013). (SCI, EI)

11. Hsien-Yeh Chen,* Ting-Ju Lin, Meng-Yu Tsai, Chiao-Tzu Su, Ruei-Hung Yuan, Chih-Chen Hsieh, Yao-Jhen Yang, Cheng-Che Hsu, Hao-Ming Hsiao, and Yin-Chu Hsua “Vapor-Based Tri-Functional Coatings,” Chemical Communications, 49,4531-4533 (2013). (SCI, EI)

12. Hao-Ming Hsiao,* Chien-Han Lin, Ying-Chih Liao, Hsien-Yeh Chen and Tzu-Wei Wang “Hemodynamic Behavior of Coronary Stents in Straight and Curved Arteries,” Current Nanoscience, in press (2013). ). (SCI, EI)

13. Chiao-Tzu Su, Ruei-Hung Yuan, Yung-Chih Chen, Ting-Ju Lin, Hsiu-Wen Chien, Chih-Chen Hsieh, Wei-Bor Tsai, Chih-Hao Chang,* Hsien-Yeh Chen*. “A Facile Approach toward Protein-Resistant Biointerfaces Based on Photodefinable Poly-p-xylylene Coating,” Colloids and Surfaces B: Biointerfaces, in press (2013). (SCI, EI)

14. Meng-Yu Tsai, Yung-Chih Chen, Ting-Ju Lin, Yin-Chu Hsu, Ching-Yu Lin, Ruei-Hung Yuan, Jiashing Yu, Ming-Sheng Teng, Michael Hirtz, Mark Hung-Chih Chen, Chih-Hao Chang*, Hsien-Yeh Chen*. “Vapor-Based Multicomponent Coatings for Antifouling and Biofunctional Synergic Modifications,” Advanced Functional Materials, in press (2013). (SCI, EI)