Professor


 

Steven S.-S. Wang Professor

王勝仕 教授

phone:(02) 3366-5870
fax:(02) 2362-3040

email: sswang

office:117

 

Lab Info

Biomolecular Engineering Laboratory

308

(02) 3366-3057

Education Background

B.S. Ch.E. National Central University, 1991
M.S. Ch.E. National Taiwan University, 1993
Ph. D. Ch.E. Texas A&M University, 2002


Research Topic

Subjects of "Nanotechnology meeting Biotechnology"

People in my lab are working on the subject of “Biotechnology meeting Nanotechnology”. In addition to concentrating on investigating the interactions between nano-materials, nano-particles, and polymers/polypeptides and biomolecules (e.g., cells and proteins), we are also working on understanding the influence and relevant cytotoxic effects of the aforesaid materials on human body. Moreover, with nano-materials and copolypeptides used the drug encapsulation material, we are trying to develop a drug release system and explore its possible therapeutic applications.

 

 

Aggregation Phenomena and Protein Folding/Unfolding Behaviors

Aggregation is a ubiquitous phenomenon significant to all aspects of science. Protein aggregation is considered to be associated with protein folding/unfolding behaviors. Using both engineering (kinetics, thermodynamics, and transport phenomenon) and biological tools, our goal is to examine the behaviors and underlying mechanisms of the said aggregation phenomena and protein folding/unfolding processes. In addition, efforts were directed toward seeking the possibilities of applying the species/materials with special aggregated structure to various fields, including tissue engineering and food science.


 

Molecular Dynamics Simulations and Modeling Approaches

We are also examining some of the aforesaid topics using the approaches including molecular dynamics, computational chemistry, bioinformatics, and modeling. Through comparing the simulation results with the experimental data, we hope to have a better understanding of the underlying molecular mechanisms of these processes of interest.

 

Recent Research Topic

1.Effect of Reduction-Oxidation Composition on the Fibrillogenesis of Amyloid Proteins. 氧化還原組成對於蛋白質類澱粉形成之影響 Sheng-Shih Wang, sponsored by National Science Council, NSC98-2221-E-002-063-MY3, 8/01/2009-7/31/2010.

 


Honor

1. National Taiwan University Distinguished Counseling Advisor Award, 2011 (台灣大學第五屆優良導師)

2. The Society of Chemical Engineering, Japan (SCEJ) Asia Research Award, Nominee, 2011

3. 化工系 99 學年度優良導師

4. 化工系 98 學年度優良導師

5. National Taiwan University Excellent Teaching Award, 2007 (工學院推薦 96 學年度教學優良教師)

6. National Taiwan University Excellent Teaching Award, 2006 (工學院推薦 95 學年度教學優良教師) 

7. Guest Editor, Journal of The Chinese Institute of Chemical Engineers (2005/6~2005/12)

8. 指導大專生參與專題研究計畫研究創作獎 ,陳雅婷 (2005)

 
The Representative Publication Recent 5-years Publication

1. P. T. Chen, T. Y. Liao, C. J. Hu, S. T. Wu, S. S.-S. Wang, and Rita P. Y. Chen, “A highly sensitive peptide substrate for detecting two Ab-degrading enzymes: neprilysin and insulin-degrading enzyme” Journal of Neuroscience Methods, 190, 57–62 (2010) (SCI).

2. S. S.-S. Wang, J. T. Lai , M. S. Huang, Clifford Y. Tai, H. S. Liu “Deactivation of isoamylase and β-amylase in the agitated reactor under supercritical carbon dioxide” Bioprocess and Biosystems Engineering, 33, 1007–1015 (2010) (SCI, EI). (合著)

3. J. K. Lai, T. H. Chuang, J. S. Jan, and S. S.-S. Wang, “Efficient and Stable Enzyme Immobilization in a Block Copolypeptide Vesicle-Templated Biomimetic Silica Support”, Colloids and Surfaces B: Biointerfaces, 80, 51–58 (2010) (SCI, EI).

4. Y. T. Hung, M. S. Lin, W. Y. Chen, and S. S.-S. Wang, “Investigating the Effects of Sodium Dodecyl Sulfate on the Aggregative Behavior of Hen Egg-White Lysozyme at Acidic pH”, Colloids and Surfaces B: Biointerfaces, 81, 141–151 (2010) (SCI, EI).

5. S. S.-S. Wang and W. S. Wen, “Examining the Influence of Ultraviolet C Irradiation on Recombinant Human γD-Crystallin”, Molecular Vision, 16, 2777–2790 (2010) (SCI).

6. S. S.-S. Wang, M. S. Lin, W. Y. Chen, “Using Isothermal Titration Calorimetry to Real-time Monitor the Heat of Metabolism: A Case Study Using PC12 Cells and A (1-40) ”, Colloids and Surfaces B: Biointerfaces 83, 307–312 (2011) (SCI, EI).

7.W. S. Wen, M. C. Hsieh, and S. S.-S. Wang, “High-Level Expression and Purification of Human D-Crystallin in Escherichia coli”, Journal of the Taiwan Institute of Chemical Engineers 42(4), 547-555 (2011) (SCI, EI).

8. S. S.-S. Wang, P. Wang, K. N. Liu, and W. S. Wen, “Fibril Formation of Bovine a-Lactalbumin is Inhibited by Glutathione”, Food Biophysics 6, 138–151 (2011) (SCI).

9. S. S.-S. Wang, Y. T. Hung, K. C. Lin, G. Y. Chen, and W. S. Wen, “Exploring the Inhibitory Activity of Short-Chain Phospholipids against Amyloid Fibrillogenesis of Hen Egg-White Lysozyme”, Biochimica et Biophysica Acta–Molecular and Cell Biology of Lipids, 1811, 301313 (2011) (SCI).

10. S. S.-S. Wang, J. K. Lai, Y. J. Lin, Y. J. Huang, and J. S. Jan, “Inhibition of Hen Egg-White lysozyme Amyloid Fibrillation by Copolypeptides”, Biopolymers, 97(2), 107116 (2012) (SCI).

11. S. S.-S. Wang, M. C. Chang, H. C. Chang, M. H. Chang, and C. Y. Tai, “Growth Behavior of Aragonite under the Influence of Magnetic Field, Temperature, and Impurity”, Industrial & Engineering Chemistry Research, 51(2), 1041–1049 (2012) (SCI, EI). (合著)

12. K. N. Liu, C. M. Lai, Y. T. Lee, S. N. Wang, J. S. Jan, H. S. Liu, and S. S.-S. Wang, “Curcumin’s Thermostability is Correlated with its Inhibitory Potency toward Amyloid Fibrillation and Fibril-induced Cytotoxicity of Lysozyme”, Biochimica et Biophysica Acta – General Subjects, 1820, 1774–1786 (2012) (SCI).

13. I. F. Nata, S. S.-S. Wang, T. M. Wu, and C. K. Lee, “b-Chitin nanofibrils for self-sustaining hydrogels preparation via hydrothermal treatment”, Carbohydrate Polymers, 90(4), 1509-1514 (2012) (SCI).

14. I. F. Nata, S. S.-S. Wang, T. M. Wu, and C. K. Lee, “Carbonaceous hydrogels based on hydrothermal carbonization of glucose with chitin nanofibers”, Soft Matter, 8, 3522-3525 (2012) (SCI).

15. J. W. Wu, C. Y. Kao, L. T. W. Lin, W. S. Wen, J. T. Lai, S. S.-S. Wang, “Human gD-crystallin aggregation induced by ultraviolet C irradiation is suppressed by resveratrol”, Biochemical Engineering Journal, 78, 189-197 (2013) (SCI, EI).

16. C. Y. Kao, J. K. Lai, T. H. Lin, Y. J. Lin, J. S. Jan, S. S.-S. Wang, “Examining the inhibitory actions of copolypeptides agains t amyloid fibrillogenesis of bovine insulin”, Biochemical Engineering Journal, 78, 181-188 (2013) (SCI, EI).

17. S. S.-S. Wang, P. L. Hsieh, P. S. Chen, Y. T. Chen, J. S. Jan, “Genipin-cross-linked poly(l-lysine)-based hydrogels: Synthesis, characterization, and drug encapsulation”, Colloids and Surfaces B: Biointerfaces 111, 423-431 (2013) (SCI, EI).

18. W. L. Chou, L. T. W. Lin, Y. Y. Shih, C. T. Li, C. Y. Kao, W. B. Tsai, S. S.-S. Wang, “Aggregation behavior of casein is correlated with the type of glycation-inducing agent”, Journal of the Taiwan Institute of Chemical Engineers (in press) (SCI, EI).

19. C. Y. Tai, M. C. Chang, C. C. Liu, S. S.-S. Wang, “Growth of calcite seeds in a magnetized environment”, Journal of Crystal Growth, 389, 5–11 (2014) (SCI, EI).

20. J. W. Wu, K. N. Liu, S. C. How, W. A. Chen, C. M. Lai, H. S. Liu, C. J. Hu, and S. S.-S. Wang, “Carnosine’s Effect on Amyloid Fibril Formation and Induced Cytotoxicity of Lysozyme”, PLoS ONE, 8(12), e81982 (SCI).