James C. Liao Professor

廖俊智 教授





Lab Info

Education Background

Research Topic

§ Biological synthesis of fuels and chemicals

§ Carbon and nitrogen assimilation

§ Metabolic engineering and synthetic biology

§ Transcriptional and metabolic networks analysis

§ Fatty acid metabolism

Recent Research Topic


§ 第三十屆中研院院士

§ National Academy of Engineering, 2013

§ White House Champion of Change in Renewable Energy, 2012

§ Presidential Green Chemistry Challenge Award, Academic

Category, 2010

§ James E. Bailey Award, Society for Biological Engineering, 2009

§ Alpha Chi Sigma Award, American Institute of Chemical

Engineers, 2009

§ Marvin J. Johnson Award, Biochemical Technology Division,

American Chemical Society, 2009

§ Charles Thom Award, Society for Industrial Microbiology, 2008

§ Merck Award for Metabolic Engineering, 2006

§ FPBE Division Award of American Institute of Chemical

Engineers, 2006

§ Fellow, American Institute for Medical and Biological

Engineering, 2002

§ National Science Foundation Young Investigator Award, 1992

The Representative Publication

§ Li, H.; P.H. Opgenorth; D.G. Wernick; S. Rogers; T.-Y.Wu; W.

Higashide; P. Malati; Y. Huo, K.-M. Cho, and J.C. Liao (2012)

Integrated electro-microbial conversion of CO2 to higher

alcohols, Science 335:1596.

§ Lan, E. I; and J.C. Liao (2012) ATP drives direct photosynthetic

production of 1-butanol in cyanobacteria, Proc. Nat. Acad. Sci.,

USA. 109:6018-23.

§ Huo,Y.; Cho,K.M.; Lafontaine, J.M.;Monte, E.; Shen, C.R.; Yan,

Y. and Liao, J.C. (2011) Conversion of proteins into biofuels by

engineering nitrogen flux, Nature Biotechnology, 29: 346-351.

§ Zhang, K.; Li, H.; Cho, K.M. and Liao, J.C. (2010) Expanding

metabolism for total biosynthesis of the nonnatural amino acid

L-homoalanine. Proc Natl Acad Sci U S A. 107(14):6234-9.

§ Atsumi,S.; Higashide, W.; and Liao, J.C. (2009) Direct recycling

of carbon dioxide to isobutyraldehyde using

photosynthesis, Nature Biotechnol, 27, 1177-1180.

§ Atsumi, S.; T. Hanai and J.C. Liao (2008) Non-Fermentative

Pathways for Synthesis of Branched-Chain Higher Alcohols as

Biofuels, Nature, 451:86-89.

§ Zhang, K., Sawaya, M.R., Eisenberg, D.S. and J.C. Liao (2008)

Expanding Metabolism for Biosynthesis of Nonnatural

Alcohols, Proc. Natl. Acad. Sci. USA105: 20653–20658

§ Atsumi, S.; A. F. Cann; M. Connor; C.R. Shen; K. M. Smith;

M.P. Brynildsen; K.J.Y. Chou; T. Hanai, and J. C. Liao (2008)

Metabolic engineering of Escherichia coli for 1-butanol

Production, Metabolic Eng. 10 (2008) 305–311.

§ Hanai, T., S. Atsumi, J. C. Liao (2007) Engineered synthetic

pathway for isopropanol production in Escherichia coli. Appl.

Env. Microbiol. 73:7814–7818

§ Hyduke, D.R., Jarboe, L.R., Tran, L.M., Chou, K.J.Y., Liao, J.C.

(2007) Integrated Network Analysis Identifies Nitric Oxide

Response Networks and dihydroxyacid dehydratase as a

Crucial Target in Escherichia coli. Proc. Natl. Acad. Sci.

USA, 104, 8484-8489.

§ Wong, W.W., T.Y. Tsai, J.C. Liao (2007) Single-cell zeroth-order

protein degradation enhances the robustness of synthetic

oscillator, Mol. Systems. Biol. 3:130.

§ Fung, E.; Wong, W.W.; Suen, J.K.; Bulter, T.; Lee, S.G.; and

Liao, J.C. (2005) A synthetic gene-metabolic oscillator, Nature,

435, 118-122.

§ Liao, J.C.; Boscolo, R; Yang, Y.L.; Tran,L.M.; Sabatti, C.; and

Roychowdhury, V. (2003) Network component analysis:

Reconstruction of regulatory signals in biological systems" Proc.

Natl. Acad. Sci. USA, 100: 15522–15527.