2012/08/28 Speaker:Prof. Guoping Chen Topic: 3D Porous Scaffolds for Tissue Engineering


announcer:Fong-Fong Liu

SpeakerProf. Guoping Chen 

Topic3D Porous Scaffolds for Tissue Engineering

Date8/28  10301200

Location化工系 工223會議室

Guoping Chen

Principal Investigator and Unit Director

Tissue Regeneration Materials Unit

International Center for Materials Nanoarchitectonics

National Institute for Materials Science, Japan

Tel: +81-29-860-4496

Fax: +81-29-860-4706

E-mail address:



Dr. Guoping Chen received his Ph.D. from Kyoto University in 1997 majoring in Biomaterials and did postdoctoral research until 2000. He became researcher in 2000 and senior researcher in 2003 at Tissue Engineering Research Center, National Institute for Advanced Industrial Science and Technology, Japan. He moved to Biomaterials Center, National Institute for Materials Science as senior researcher in 2004 and was group leader from January, 2007 to March, 2011. He has been PI and unit director since April, 2011. His research interests include polymeric porous scaffolds, biomimetic biomaterials, micro-patterning, surface modification and tissue engineering. He has authored more than 190 publications with more than 2500 citations. He has documented 22 patents and given more than 70 invited and plenary presentations. He has received several awards such as Young Scientist Award from the Japanese Society for Biomaterials in 2001, Original Award from the Japanese Society of Artificial Organs in 2002, Tsukuba Award of Chemical and Bio-Technology from the Tsukuba Foundation for Chemical and Bio-Technology in 2005, Best Research and Collaboration Award from the Science Academy of Tsukuba in 2010 and Best Presentation Award form the Science Academy of Tsukuba in 2012. He is regional editor of the Journal of Biomaterials and Tissue Engineering and council member of the Tissue Engineering and Regenerative Medicine International Society’s Asian-Pacific Chapter (TERMIS-AP).


Representative papers:

1. Biomaterials, 33, 6140-6146 (2012).

2. Biomaterials, 33, 2025-31 (2012).

3. Advanced Materials, doi: 10.1002/adma.201200237 (2012).

4. Biomaterials, 32, 9658-9666 (2011).

5. Biomaterials, 32, 2489-2499 (2011).

6. Advanced Materials, 22, 3042-3047 (2010).

7. Biomaterials, 31: 5825-5835 (2010).

8. Biomaterials, 31: 2141-2152 (2010).

9. Journal of Biological Chemistry, 284: 31164-31173 (2009).

10. Biomaterials, 29, 3438-3443 (2008).

11. Biomaterials, 29, 23-32 (2008).

12. Advanced Materials, 19, 3633-3636 (2007).

13. Biomaterials, 26, 2559-2566 (2005).

14. Journal of Biomedical Materials Research, 67, 1170-1180 (2003).

15. Macromolecular Bioscience, 2, 67-77 (2002).

16. Biomaterials, 22, 2563-2567 (2001).

17. Advanced Materials, 12, 455-457 (2000).

3D Porous Scaffolds for Tissue Engineering


Guoping Chen


Tissue Regeneration Materials Unit, International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Tsukuba, Japan


Tissue engineering has been rapidly developed in recent years to restore or replace the lost or malfunctioned tissues and organs. Biomaterials and scaffolds play an important role in tissue engineering to control cell functions and to modulate neo-tissue formation by mimicking the functional and structural characteristics of the native extracellular matrices. In this talk, I will introduce a few types of novel scaffolds developed by our group. The first type is hybrid scaffolds of synthetic polymers and naturally-derived polymers. Collagen sponge or microsponges were introduced in the pores or openings of mechanically strong synthetic polymer skeletons to construct the hybrid structures. The skeletons of synthetic polymers provided high mechanical strength, while the collagen sponge and mircosponges facilitated cell seeding and distribution. The hybrid scaffolds were used for cartilage tissue engineering. The second type is funnel-like collagen sponges that were prepared by using embossing ice particulates as a template. The funnel-like collagen sponges facilitated cell seeding, cell penetration, and distribution throughout the scaffold, and accelerated the regeneration of skin dermal tissue. The third type is biomimetic autologous ECM scaffold prepared by 3D culture of cells in a template that can be selectively removed after cell culture. The autologous ECM scaffolds showed excellent biocompatibility and can be used for tissue engineering to avoid any adverse host inflammatory and immune responses.