教授介紹


 

謝學真 教授

Hsyue-Jen Hsieh

電話(02)2363-3097 (02)3366-3994
傳真(02)23623040

電子郵件 hjhsieh

辦公室:114

 

研究室資料

生醫工程研究室

104

(02)3366-3016

學經歷

國立台灣大學  化工學士,1983
國立台灣大學  化工碩士,1985
美國賓州州立大學  化工博士,1992


研究主題

動物細胞培養工程
動物細胞能生產多種高附加價值之生物產品,例如:生長因子、溶血栓藥物等。本研究室探討動物細胞附著及生長模式,以及各種影響因素(如:培養基材、胞外間質、培養液成份、剪力作用等)之效應。

 

剪力對內皮細胞之調控
血管內皮細胞位於血管最內層,直接承受血流產生之剪力,並據以調節血管生理功能,內皮細胞也在動脈硬化等血管病變過程中扮演重要角色。本研究室使用剪流裝置探討剪力對內皮細胞功能之調控,其中包括胞內活性氧族群、蛋白激酶、基因表現等之變化。

 

酵素應用
酵素之應用範圍相當廣泛,包括了工業生產、臨床醫療等方向。本研究室以轉化酵素為模式,比較各種固定化方法及載體之影響。另外亦探討溶菌酵素復性過程,設法以透析等方式提高其復性效果,改良目前採用之稀釋復性程序。  
 

最新研究

1.鹼性多醣/酸性多醣複合生醫材料之製備、分析及應用 H.J. Hsieh, sponsored by 97-2221-E-002-023-MY2 NT$ 1,084,000, 8/1/2009-7/31/2010
 


榮譽獎項

 
代表著作 近五年著作

1. C.Y. Hsieh, H.Y. Hsiao, W.Y. Wu, C.A. Liu, Y.C. Tsai, Y.J. Chao, D.L. Wang, H.J. Hsieh, “Regulation of shear-induced nuclear translocation of the Nrf2 transcription factor in endothelial cells,” Journal of Biomedical Science 16, 12 (2009). (SCI)

2. N.Y. Yuan, Y.A. Lin, M.H. Ho, D.M. Wang, J.Y. Lia, H.J. Hsieh, “Effects of the cooling mode on the structure and strength of porous scaffolds made of chitosan, alginate, and carboxymethyl cellulose by the freeze-gelation method,” Carbohydrate Polymers 78, 349-356 (2009). (SCI) (合著)

3. P.H. Chen, T.Y. Kuo, D.M. Wang, J.Y. Lai, H.J. Hsieh, Use of Chitosan as a Material Stabilizer for Acidic Polysaccharides, Materials Science Forum 638-642, 570-575 (2010) (EI) (合著)

4. S.W. Hsiao, D.V.M. Thien, M.H. Ho, H.J. Hsieh, C.H. Li, C.H. Hung, H.H. Li, “Interactions between chitosan and cells measured by AFM,” Biomedical Materials 5, 054117 (8pp) (2010). (SCI, EI)

5. P.H. Chen, T.Y. Kuo, J.Y. Kuo, Y.P. Tseng, D.M. Wang, J.Y. Lai, H.J. Hsieh, “Novel chitosan–pectin composite membranes with enhanced strength, hydrophilicity and controllable disintegration,” Carbohydrate Polymers 82, 1236-1242 (2010). (SCI, EI)

6. H.K. Wang, C.H. Tsai, K.H. Chen, C.T. Tang, J.S. Leou, P.C. Li, Y.L. Tang, H.J. Hsieh, H.C. Wu, C.M. Cheng, “Cellulose-based diagnostic devices for diagnosing serotype-2 dengue fever in human serum,” Advanced Healthcare Materials http://onlinelibrary.wiley.com/doi/10.1002/adhm.201300150/abstract (in press). (SCI)

7. R.Y. Tsai, S.C. Hung, J.Y. Lai, D.M. Wang, H.J. Hsieh, “Electrospun chitosan-gelatin-polyvinyl alcohol hybrid nanofibrous mats: production and characterization,” Journal of the Taiwan Institute of Chemical Engineers http://dx.doi.org/10.1016/j.jtice.2013.11.003 (in press). (SCI, EI)

8. R.Y. Tsai, P.W. Chen, T.Y. Kuo, C.M. Lin, D.M. Wang, T.Y. Hsien, H.J. Hsieh, “Chitosan/pectin/gum Arabic polyelectrolyte complex: Process-dependent appearance, microstructure analysis and its application,” Carbohydrate Polymers 101, 752-759 (2014). (SCI, EI)

9. Hsieh HJ, Liu CA, Huang B, Tseng AHH, Wang DL. “Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications,” Journal of Biomedical Science 21, 3 (2014). (SCI)