研究主題

生物材料
生物材料和蛋白質或細胞間的交互作用，決定著醫療器材的成功與否，本實驗室著重於研究生物材料和生物系統的交互作用，以期設計出最佳的生物材料。研究重點包括： 1. 生物材料和生物系統的交互作用之機制 2. 生物材料之改質技術 3. 生物材料之生物相容性探討

組織工程
基材與細胞的交互作用在組織工程的成敗中佔有關鍵的地位，本實驗室著重於研究基材的特性對於細胞生長與分化功能的影響，以其設計出適合組織工程用的基材。研究重點包括： 1. 細胞在基材上之生長與分化功能探討 2. 基材改質以促進細胞生長與分化功能 3. 材料表面的奈米結構對於細胞生長和分化的影響

最新研究

1. 紡織產業卓越創新研究中心業務推展 NT$ 450,000, 紡織研究所, 03/01/2008-12/31/2008

2. 製備具有微圖樣的聚電解質多層膜及其在細胞工程的應用 NT$ 970,000, 97-2628-E-002-028-MY2, 08/01/2008-07/31/2009

榮譽獎項

代表著作 所有著作

1. W.-B. Tsai, Q. Shi, J. M. Grunkemeier, C. McFarland, T. A. Horbett. “Platelet adhesion to radiofrequency glow-discharge-deposited fluorocarbon polymers preadsorbed with selectively depleted plasmas show the primary role of fibrinogen”, J Biomater Sci Polym Edn 15(7):817-40, 2004. (SCI, EI)

2. Wei-Bor Tsai, Ta-Chin Wei, Mei-Chiao Lin, Jie-Ying Wang, and Chun-Hong Chen. “The effect of radio-frequency glow discharge treatment of polystyrene on the behavior of porcine chondrocytes in vitro”, J Biomater Sci Polym Edn, 16, 699-714, 2005. (SCI, EI)

3. Wei.-Bor Tsai and Min-Cheng Wang, “The effect of an avidin-biotin binding system on chondrocyte adhesion, growth and gene expression”, Biomaterials, 26(16): 3141-51, 2005. (SCI, EI)

4. Wei-Bor Tsai and Min-Cheng Wang. “The effects of an avidin-biotin binding system on chondrocyte adhesion and growth on biodegradable polymers”, Macromolecular Bioscience 5: 214-221, 2005. (SCI, EI)

5. Shiao-Wen Tsai, Yu-Hui Cheng and Wei-Bor Tsai, “Heparin Modulates Human Osteosarcoma (MG-63) Activities on Collagen-Coated Substrata”, J. Chin. Inst. Chem. Engrs., Vol. 36(6): 661-668, 2005. (SCI, EI)

6. Wei-Bor Tsai , Chun-Hong Chen, Jing-Fu Chen and Ken-Yuan Chang, “The effects of types of degradable polymers on porcine chondrocyte adhesion, proliferation and gene expression”, Journal of Materials Science: Materials in Medicine, 17: 337–343, 2006. (SCI, EI)

7. H. Thissen, K.-Y. Chang, T.A. Tebb, W.-B. Tsai, V. Glattauer, J.A.M. Ramshaw, J.A. Werkmeister, “Synthetic biodegradable microparticles for articular cartilage tissue engineering” Journal of Biomedical Materials Research: Part A, 77A: 590–598, 2006. (SCI, EI)

8. 林中英、蔡偉博 「生物材料應用於人工血液的發展與應用」,化學季刊‧第64卷(1)：97-104, 2006。

9. Wei-Bor Tsai, Peng-Yuan Wang, Yung Chang and Min-Cheng Wang, “Fibronectin and culture temperature modulate the efficacy of an avidin-biotin binding system for chondrocyte adhesion and growth on biodegradable polymers”, Biotechnology and Bioengineering, 98(2): 498-507, 2007. (SCI, EI)

10. Hsuan-Liang Liu, Ching-Tao Yang, Jian-Hua Zhao, Chih-Hung Huang, Hsin-Yi Lin, Hsu-Wei Fang, Yih Ho, Wei-Bor Tsai, “Molecular Dynamics Simulations to Investigate the Effects of Zinc Ions on the Structural Stability of the c-Cbl RING Domain”, Biotechnol Prog., 23(5):1231-1238, 2007. (SCI, EI)

11. Jian-Hua Zhao, Hsuan-Liang Liu, Hsin-Yi Lin, Chih-Hung Huang, Hsu-Wei Fang, Shiao-Shing Chen, Yih Ho, Wei-Bor Tsai, Wen-Yih Chen, “Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases”, Perspectives in Medicinal Chemistry, 1:39-48, 2007.

12. Hsu-Wei Fang, Hsien-Chieh Wang, Teh-Hua Tsai, Wei-Bor Tsai, Shao-Yi Hou, Hsuan-Liang Liu, Wun-Hsin Lee, Yung-Chang Lu, Chun-Hsiung Huang, “An accelerated wear testing with microfabricated surface to evaluate the lubrication ability of biomolecules on polyethylene”, Journal of Applied Polymer Science, 2007, accepted. (SCI, EI)

13. Jian-Hua Zhao, Ching-Tao Yang, Josephine W. Wu, Wei-Bor Tsai, Hsin-Yi Lin, Hsu-Wei Fang, Yih Ho, Hsuan-Liang Liu, “RING domains functioning as E3 ligases reveal distinct structural features: a molecular dynamics simulation study”, Journal of Biomolecular Structure & Dynamics, 26 (1), 65-74 (2008) (SCI)

14. Hsu-Wei Fang, Hsien-Chieh Wang, Teh-Hua Tsai, Wei-Bor Tsai, Shao-Yi Hou, Hsuan-Liang Liu, Wun-Hsin Lee, Yung-Chang Lu, Chun-Hsiung Huang, “An accelerated wear testing with microfabricated surface to evaluate the lubrication ability of biomolecules on polyethylene”, Journal of Applied Polymer Science, 108:2428-2437, 2008. (SCI, EI)

15. Jian-Hua Zhao, Hsuan-Liang Liu, Yi-Fan Liu, Hsin-Yi Lin, Hsu-Wei Fang, Yih Ho, Wei-Bor Tsai, “Molecular Dynamics Simulations to Investigate the Aggregation Behaviors of the Aβ(17-42) Oligomers”, Journal of Biomolecular Structure & Dynamics, 26(4):481-490, 2009. (SCI, EI)

16. Peng-Yuan Wang, Hsiang-Hong Chow, Hsu-Wei Fang, Wei-Bor Tsai, “Modulation of gene expression of rabbit chondrocytes by dynamic compression in polyurethane scaffolds with collagen gel encapsulation”, Journal of Biomaterials Applications, 2008, in press. (SCI, EI)

17. Jung-Yen Yang, Yen-Chung Ting, Juin-Yih Lai, Hsuan-Liang Liu, Hsu-Wei Fang, Wei-Bor Tsai, “Quantitative analysis of osteoblast-like cells (MG63) morphology on nanogrooved substrata with various groove and ridge dimensions”, Journal of Biomedical Materials Research: Part A, 2008, in press. (SCI, EI)

18. Wei-Bor Tsai, Ying-Hao Chen, Hsiu-Wen Chien, “Collaborative cell-resistant properties of polyelectrolyte multilayer films and surface PEGylation on reducing cell adhesion to cytophilic surfaces”, Journal of Biomaterials Science: Polymer Edition, 2008, in press. (SCI, EI)

19. Hsiu-Wen Chien, Tsung-Yao Chang, Wei-Bor Tsai, “Spatial control of cellular adhesion using photo-crosslinked micropatterned polyelectrolyte multilayer films”, Biomaterials, 2008, accepted.

20. Wei-Bor Tsai, Yen-Chung Ting, Jung-Yen Yang, Juin-Yih Lai, Hsuan-Liang Liu, “Fibronectin modulates the morphology of osteoblast-like cells (MG-63) on nano-grooved substrates”, Journal of Materials Science: Materials in Medicine, 2008, accepted.

Books

1. W.-B. Tsai and C.-A. Dai. “Interactions of Cells with Biomaterial Nanostructured Surfaces”. In Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, Vol 1: Biomaterials. Edited by H. S. Nalwa. American Scientific Publishers, Baltimore, USA, 2005. (invited review chapter, 合著)

Patents

1. J.A. Werkmeister, W.-B. Tsai, J.A.M. Ramshaw, H. Thissen, K.-Y. Chang, Method and device for tissue repair

Patent Number WO200262357-A1, Publication Date: 15 August 2002,

Patent Number CA2437212, Publication Date: 15 August 2002 加拿大

Patent Number EP1365784, Publication Date: 3 December 2003 歐盟

2. 「使用一裝置在製造一醫藥用品上之用途、製造一供修補一主體中害病的或受損的組織之裝置的方法以及具類似組織特性之裝置」,中華民國專利,證書號：I258372, 2006/07/21-2022/02/03 .

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