研究主題

研究神經疾病之發生機制
嘗試以不同之工程與生化方法或工具來探討疾病方面，特別是在神經系統方面之疾病 (例如：愛滋海默症，巴金斯症，狂牛病等 Amyloid diseases，青光眼，及白內障)在細胞層次之發生機制，進而尋求有效之抑制分子與預防方法。主要應用之領域：細胞工程、細胞生物學、蛋白質工程、神經科學。

生化分子在不同培養環境下之生理反應及行為
嘗試以神經細胞、動物細胞與微生物在不同培養系統(如：微重力場生化反應器)下之生理反應。

奈米技術或材料在生物領域上之應用
將著重於利用生物分子之特殊性質來合成具奈米等級之材料；或發展生物分子及奈米材料之偵測系統。

最新研究

1. Examining the aggregation and cytotoxicity mechanisms of amyloid diseases and searching for the potential inhibitory molecules. 探討類澱粉症之一般化聚集與毒性機制並尋找可行之抑制分子物質 Sheng-Shih Wang, sponsored by National Science Council, NSC95-2221-E-002-104-MY3, 8/01/2008-7/31/2009.

榮譽獎項

1. Guest Editor, Journal of The Chinese Institute of Chemical Engineers (2005/6~2005/12)

2. 工學院推薦 95 學年度教學優良教師

3. 工學院推薦 96 學年度教學優良教師

代表著作 所有著作

1. K. M. Hawkins, S. S.-S. Wang, D. M. Ford, and D. F. Shantz, “Poly-L-Lysine Templated Silicas: Using Polypeptide Secondary Structure to Control Oxide Pore Architectures,” Journal of American Chemical Society, 126(29), 9112-9119 (2004) (SCI, EI).

2. S. S.-S. Wang, C. K. Chang, and H. S. Liu, “A Study on the Refolding of Lysozyme Using Fed-Batch and Step-Addition Strategies,” Journal of The Chinese Institute of Chemical Engineers, 35(4), 389-398 (2004) (SCI, EI). (合著)

3. A. L. Simonian, T. A. Good, S. S.-S. Wang, and James R. Wild, “Nanoparticle-based Optical Biosensors for the Direct Detection of Organophosphate Chemical Warfare Agents and Pesticides,” Analytica Chimica Acta, 534, 60-77 (2005) (SCI, EI).

4. S. S.-S. Wang, T. A. Good, and D. L. Rymer, “The Influence of Phospholipid Membranes on Bovine Calcitonin Structure and Toxicity,” International Journal of Biochemistry and Cell Biology, 37(8), 1656-1669 (2005) (SCI).

5. S. S.-S. Wang, T. A. Good, and D. L. Rymer, “The Influence of Phospholipid Membranes on Bovine Calcitonin Secondary Structure and Amyloid Formation,” Protein Science, 14, 1419-1428 (2005) (SCI).

6. S. S.-S. Wang, Y. T. Chen, and S. W. Chou, “Inhibition of Amyloid Fibril Formation of -Amyloid Peptides Via the Amphiphilic Surfactants,” Biochimica et Biophysica Acta – Molecular Basis of Disease, 1741, 307-313 (2005) (SCI).

7. S. S.-S. Wang and T. A. Good, “An Overview of Alzheimer’s Disease,” Journal of The Chinese Institute of Chemical Engineers, 36(6), 533-559 (2005) (SCI, EI).

8. S. S.-S. Wang, Y. T. Chen, P. H. Chen, and K. N. Liu, “A Kinetic Study on the Aggregation Behavior of -Amyloid Peptides in Different Initial Solvent Environments,” Biochemical Engineering Journal, 29, 129-138 (2006) (SCI, EI).

9. S. S.-S. Wang, C. K. Chang, and H. S. Liu, “Step Change of Mobile Phase Flow Rates to Enhance Protein Folding in Size Exclusion Chromatography,” Biochemical Engineering Journal, 29, 2-11 (2006) (SCI, EI). (合著)

10. S. S.-S. Wang, Che-Kuei Chang and Hwai-Shen Liu, “Effect of Glutathione Redox System on Lysozyme Refolding in Size Exclusion Chromatography,” Food and Bioproducts Processing, 84(C1): 18-27 (2006) (SCI). (合著)

11. S. S.-S. Wang, Po-Han Chen, and Ying-Tz Hung, “Examining the Effects of p-Benzoquinione and Melatonin on Amyloid Fibrillogenesis of Hen Egg-White Lysozyme,” Journal of Molecular Catalysis B: Enzymatic, 43, 49-57 (2006) (SCI, EI).

12. V. H. Lieu, J. W. Wu, S. S.-S. Wang, and C. H. Wu, “Inhibition of Amyloid Fibrillization of Hen Egg-White Lysozymes by Rifampicin and p-Benzoquinone,” Biotechnology Progress, 23, 698-706 (2007) (SCI, EI).

13. S S.-S. Wang, J. W. Wu, Y. T. Hung, and P. Wang, “The Formation of Amyloid-Like Hen Egg-White Lysozyme Species Induced by Temperature and Urea Concentration-Dependent Denaturation,” Korean Journal of Chemical Engineering, 24 , 787-795 (2007) (SCI).

14. M. S. Lin, H. M. Chiu, F. J. Fan, H.T. Tsai, S. S.-S. Wang, Y. C., W. Y. Chen, “Kinetics and enthalpy measurements of interaction between beta-amyloid and liposomes by surface plasmon resonance and isothermal titration microcalorimetry,” Colloids and Surfaces B: Biointerfaces, 58, 231-236 (2007) (SCI, EI).

15. S. S.-S. Wang, C. K. Chang, and H. S. Liu, “Effect of Sample Loop Dimension on Lysozyme Refolding in Size Exclusion Chromatography,” Journal of Chromatography A, 1161, 56-63 (2007) (SCI, EI). (合著)

16. M. S. Lin, H. M. Chiu, F. J. Fan, H.T. Tsai, S. S.-S. Wang, Y. C., W. Y. Chen, “Kinetics and enthalpy measurements of interaction between beta-amyloid and liposomes by surface plasmon resonance and isothermal titration microcalorimetry,” Colloids and Surfaces B: Biointerfaces, 58(2), 231-236 (2007) (SCI, EI).

17. M. S. Lin, L. Y. Chen, H .T. Tsai, S. S.-S. Wang, Y. Chang, A. Higuchi, and W. Y. Chen, “Investigation of the mechanism of beta-amyloid fibril formation by kinetic and thermodynamic analyses,” Langmuir, 24(11), 5802-5808 (2008) (SCI, EI).

18. S. S.-S. Wang and K. N. Liu, “Membrane dipole potential of interaction between amyloid protein and phospholipid membranes is dependent on protein aggregation state,” Journal of The Chinese Institute of Chemical Engineers, 39(4), 321-328 (2008) (SCI, EI).

19. M. S. Lin, L .Y. Chen, S. S.-S. Wang, Y. Chang, and W. Y. Chen, “Examining the levels of ganglioside and cholesterol in cell membrane on attenuation the cytotoxicity of beta-amyloid peptide,” Colloids and Surfaces B: Biointerfaces, 65(2), 172-177 (2008) (SCI, EI).

20. S. S.-S. Wang, H. S. Chao, H. L. Liu, and H. S. Liu, “Stability of Hen Egg-White Lysozymes during Denaturation is Enhanced via Pretreatment in Supercritical Carbon Dioxide,” Journal of Bioscience and Bioengineering, (accepted) (SCI, EI). (合著)