研究主題

熱力學相平衡、超臨界流體系統之計算與實驗、程序模擬與計算
相平衡是熱力學與分離技術上之重要課題，也是本研究室致力研究的目標。本研究室之研究項目包括: (1)應用改良之配位數模式，提出長鏈型狀態方程式，並應用至高分子溶液之汽液相平衡計算。(2)針對汽液相平衡，及固體在超臨界流體中之溶解度，提出改良之混和規則，並得到通用及具有預估能力之關聯。(3)高分子系統、超臨界萃取系統、界面活性劑系統、以及多成分系統之相平衡研究。(4)利用局部組成模式，提出擴散係數關聯方法，並進行其他熱力性質，如表面張力之理論計算。(5)在實驗方面，進行常壓與高壓之汽液相平衡測量，固體分子在超臨界二氧化碳中溶解度之量測與關聯，以及應用超臨界二氧化碳合成導電性高分子材料之研究。(6)應用計算流體力學、化工程序模擬軟體、程序整合技術，進行工業製程之節能計算，及清潔製程之分析與設計，達成高效率與低污染之工業製程改善，此研究並與中油公司及英國進行國際合作。

最新研究

1. Green Chemical Process Technology (Phase 2), Part A1. Micronization of Pharmaceutical Compounds and Food Additives Using Supercritical Fluid Technology. 綠色化學程序尖端技術（第二期）：子計畫A1 Sponsored by the Ministry of Economic Affairs, 1/12/2008-30/11/2009 96-EC-17-A-09-S1-019

2. Solid Solubility Measurement, Model Correlation, and Particle Micronization of Pharmaceutical Compounds in Supercritical Carbon Dioxide (1/3) 藥物分子在超臨界二氧化碳中之固體溶解度量測、模式關聯、與微粒化研究(1/3) NSC97-2221-E-002-087-MY3, NT$ 1,250,000, 1/8/2008-31/7/2009

榮譽獎項

1. 國立台灣大學傅斯年獎，2005年9月

 

2. 化工技術獎（團體獎）2006. 11.24本人參與台大化工系執行經濟部學界科專計畫，於2006. 11.24獲得台灣化學工程學會化工技術獎（團體獎）

 

代表著作 所有著作

1. M. Tang, T. B. Du and Y. P. Chen, “Sorption and Diffusion of Supercritical Carbon Dioxide in Polycarbonate”, J. of Supercritical Fluids, 28, 207-218 (2004) (SCI, EI)

 

2. J. S. Cheng, M. Tang and Y. P. Chen, “Correlation and Comparison of the Infinite Dilution Activity Coefficients in Aqueous and Organic Mixtures from a Modified Excess Gibbs Energy Model”, Fluid Phase Equilibria, 217, 205-216 (2004) (SCI, EI)

 

3. M. Tang, Y. C. Huang and Y. P. Chen, “Sorption and Diffusion of Supercritical Carbon Dioxide into Polysulfone”, J. Appl. Polym. Sci., 94, 474-482 (2004) (SCI, EI)

 

4. C. Y. Huang, M. Tang and Y. P. Chen, “Solid-Liquid Equilibria for 3-Aminophenol + a-Aminophenol, 4-(Acetylamino)toluene + 2-(Acetylamino)toluene and 3,4,5-Trimethoxybenzoic Acid + 2,4,5-Trimethoxybenzoic Acid”, J. Chem. Eng. Data, 50, 40-43 (2005) (SCI, EI)

 

5. J. C. Tsai and Y. P. Chen, “VLE Calculation for Non-polar Fluid Mixtures and Polymer Solutions Using the SAFT-VR Type Equation of State”, Fluid Phase Equilibria, 232, 100-112 (2005) (SCI, EI)

 

6. Y. P. Chen, M. Tang and J. C. Kuo, “Solid-Liquid Equilibria for Binary Mixtures of N-Phenylacetamide with 4-Aminoacetophenone, 3-Hydroxyacetophenone and 4-Hydroxyacetophenone”, Fluid Phase Equilibria, 232, 182-188 (2005) (SCI, EI)

 

7. J. S. Cheng and Yan-Ping Chen, “Correlation of the Critical Micelle Concentration for Aqueous Solutions of Nonionic Surfactants”, Fluid Phase Equilibria,  232, 37-43 (2005) (SCI, EI)

 

8. C. H. Cheng and Y. P. Chen, “Vapor-liquid equilibria of carbon dioxide with isopropyl acetate, diethyl carbonate and ethyl butyrate at elevated pressures”, Fluid Phase Equilibria, 234, 77-83 (2005) (SCI, EI)

 

9. C. S. Su and Y. P. Chen, “Recrystallization of Salicylamide Using a Batch Supercritical Anti-Solvent Process”, Chemical Engineering and Technology, 28, 1177-1181 (2005) (SCI, EI)

 

10. C. H. Cheng and Y. P. Chen, “Vapor-Liquid Equilibria for the Ternary System of Carbon Dioxide + Ethanol + Ethyl Acetate at Elevated Pressures”, Fluid Phase Equilibria, 242, 169-175 (2006) (SCI, EI)

 

11. C. F. Chen, C. S. Chang, Y. P. Chen, T. S. Lin, C. Y. Su and S. Y. Lee, “Application of Supercritical Fluid in Alloplastic Bone Graft: A Novel Method and in Vitro Tests”, Ind. Eng. Chem. Res., 45, 3400-3405 (2006) (EI, SCI)

 

12. C. H. Cheng, Muoi Tang and Y. P. Chen, “Vapor-Liquid Equilibria for the Ternary Mixture of Carbon Dioxide + 1-Proponal + Propyl Acetate”, Fluid Phase Equilibria, 248, 89-95 (2006) (EI, SCI)

 

13. Shi-Yue Huang, Muoi Tang, Sheau-Ling Ho and Yan-Ping Chen, “Solubility of N-Phenylacetamide, 2-Methyl- N-Phenylacetamide and 4-Methyl- N-Phenylacetamide in Supercritical Carbon Dioxide”, J. Supercrit. Fluids, 42, 165-171 (2007) (SCI, EI)

 

14. Chie-Shann Su and Yan-Ping Chen, “Correlation for the Solubilities of Pharmaceutical Compounds in Supercritical Carbon Dioxide “, Fluid Phase Equilibria, 254, 167-173 (2007) (SCI, EI)

 

15. Chie-Shann Su and Yan-Ping Chen, “Measurement and Correlation for the Solid Solubility of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Supercritical Carbon Dioxide”, J. Supercrit. Fluids, 43, 438-446 (2007) (SCI, EI)

 

16. Muoi Tang, Wei-Heng Huang and Yan-Ping Chen, “Comparisons of the Sorption and Diffusion of Supercritical Carbon Dioxide into Polycarbonate and Polysulfone”, J. Chin. Inst. Chem. Eng., 38, 419-424 (2007) (SCI, EI)

 

17. Yun-Ping Chang, Muoi Tang and Yan-Ping Chen, “Micronization of Sulfamethoxazole Using the Supercritical Anti-Solvent Process”, J. Materials Sci., 43, 2328-2335 (2008) (EI, SCI)

 

18. C. S. Su and Yan-Ping Chen, “Measurement and Correlation for the Solid Solubility of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Supercritical Carbon Dioxide”, J. Supercritical Fluids, 43, 438-446 (2008) (SCI, EI)

 

19. C. S. Su and Yan-Ping Chen, “Recrystallization of Pharmaceuticals Using the Batch Supercritical Anti-Solvent Process”, Chemical Engineering & Processing, 48, 92-100 (2009) (SCI, EI)

 

20. Y. P. Chen, Y. M. Chen and M. Tang, “Solubilities of Cinnamic Acid, Phenoxyacetic Acid and 4-Methoxyphenylacetic Acid in Supercritical Carbon Dioxide. Fluid Phase Equilibria, 275, 33-38 (2009) (SCI, EI)

 

 

 

Conference Chairman and Invited Speaker

 

1. C. S. Su and Y. P. Chen, “Recrystallization of Acetaminophen and Phenacetin Using Batch Supercritical Anti-Solvent Precipitation”, Proc. 2004 International Conference on Supercritical Fluid Technology, November 3-5, Taipei, Taiwan, 2004. (Session Chairman)

 

2. C. S. Su, M. Tang and Y. P. Chen, “Calculation of Volume Expansion for High Pressure Anti-Solvent Processes Using the Volume-Translated Peng-Robinson Equation of State”, Proc. The 4th International Symposium on Supercritical Fluid Technology for Energy, Environment and Electronics Applications (Super Green 2005), November 20-23, Taipei, Taiwan, 2005 (Chairman of the Symposium)

 

3. Y. P. Chang, C. S. Su and Y. P. Chen, “Recrystallization and Micronization of Pharmaceuticals Using the Continuous Supercritical Anti-Solvent (SAS) Process”, Proc. The 4th International Symposium on Supercritical Fluid Technology for Energy, Environment and Electronics Applications (Super Green 2005), November 20-23, Taipei, Taiwan, 2005 (Chairman of the Symposium)

 

4. C. F. Chen, C. S. Chang, Y. P. Chen and T. S. Lin, “Applications of Supercritical Fluid in Alloplastic Bone Craft”, Proc. The 4th International Symposium on Supercritical Fluid Technology for Energy, Environment and Electronics Applications (Super Green 2005), November 20-23, Taipei, Taiwan, 2005 (Chairman of the Symposium)

 

5. P. J. Lien and Yan-Ping Chen, “The Micronization and Nanoization of Pharmaceutical Particle – Amoxicillin by Supercritical Anti-Solvent Pilot Facility”, Proc. The 4th International Symposium on Supercritical Fluid Technology for Energy, Environment and Electronics Applications (Super Green 2005), November 20-23, Taipei, Taiwan, 2005 (Chairman of the Symposium)

 

6. J. J. Chen, C. S. Su, M. Tang and Y. P. Chen, “Recrystallization and Micronization of Polymeric and Pharmaceutical Materials Using the Supercritical Anti-Solvent Method”, Proc. ISHR & ICSTR 2006, August 5-9, Sendai, Japan, 2006 (Invited Speaker)

 

7. C. S. Su, M. Tang and Y. P. Chen, “Calculation of Thermodynamic Properties Using the Predictive Soave-Redlich-Kwong (SPRK) Equation of State for the Supercritical Anti-Solvent Process”, to be Presented at the 8th International Symposium on Supercritical Fluids, November 5-8, Kyoto, Japan, 2006 (International Organization Committee)

 

8. Yan-Ping Chen, Jiun-Jen Chen and Chan-Pong Iun, “Applications of Supercritical Fluid Technology: The Micronization of Pharmaceutical Compound and Surface Modification of Polymer”, Super Green 2007 International Meeting, November 28-30, Seoul, Korea, 2007. (Keynote Speaker)

 

9. Yan-Ping Chen, “Experiences in Having Reviewers from the Washington Accord (IEET)”, JABEE Symposium/Workshop, December 13, Tokyo, Japan, 2007 (invited Speaker).