研究主題

生化程序工程
本實驗室著重生化程序工程及其相關領域研究，其包括生化反應及分離技術。在反應技術部份曾有再生資源的生化轉換、油污生物降解、週期式操作及相關動態行為、醱酵即時抑制物移除、昆蟲細胞與桿狀病毒系統生產藥用蛋白、無血清培養基、添加劑增加氧氣傳遞及提昇產量、及異澱粉酵素之應用(固定化技術、超臨界流體下之反應)。在下游程序則包含蛋白質／酵素分離技術(吸附、層析、泡沫分離)，蛋白質穩定性與復性。

超重力系統
超重力系統(旋轉填充床)可大幅提高質傳效果，進而縮小系統設備。本實驗室已成功應用於吸收氣提吸附等單元操作， 同時設計基礎研究亦在進行中。

最新研究

1. 以大小排阻層析法進行蛋白質復性之研究 (1/3)
2. 「綠色化學程序」尖端技術四年計劃

榮譽獎項

代表著作

1. Y. C. Lee, K. J. Stebe, H. S. Liu , S. Y. Lin, “ Adsorption and Desorption Kinetics of C m E 8 on Impulsively Expanded or Compressed Air-Water Interfaces ,” Colloids Surf. A , 220, 139-150 (2003) (SCI, EI)

2. S. Y. Lin, Y. C. Lee, M. W. Yang, H. S. Liu , “ A Study on Surface Equation of State of Nonionic C m E n Surfactants,” Langmuir 19, 3164-3171 (2003) (SCI, EI)

3. 劉懷勝 , 張哲魁 “ 生物製程與化工 ” 化工技術 May 140-149 （ 2003 ）

4. Y. C. Chen, C. C. Lin and H. S. Liu “Adsorption of dodecane from water in a rotating packed bed” J. Chin. Inst. Chem. Engrs. 35(5), 531-538 (2004) (SCI, EI)

5. S. S. Wang, C. K. Chang, M. Z. Kao and H. S. Liu “A Study on the Refolding of Lysozyme Using Fed-Batch and Step-A dd ition Strategies” J. Chin. Inst. Chem. Engrs. 35(4), 389-398 (2004) (SCI, EI)

6. Y. S. Chen, H. S. Liu , C. C. Lin , W. T. Liu “Micromixing in a Rotating Packed Bed” J. Chem. Eng. Jp. , 37(9), 1122-1128 (2004) (SCI, EI)

7. H. L. Liu , W. C. Hsieh and H. S. Liu “Molecular Dynamics Simulations to Determine the Effect of Supercritical Carbon Dioxide on the Structure Integrity of Egg Hen Lysozyme” Biotech. Progr. , 20, 930-938 (2004) (SCI, EI)

8. Y . S. Chen, C. C. Lin , and H. S. Liu “ Mass Transfer in a Rotating Packed Bed with Various Radii of the Bed” Industrial & Engineering Chemistry Research 44(20), 7868-7875 (2005) (SCI, EI)

9. Y. C. Chen, C. C. Lin and H. S. Liu “Mass Transfer in a Rotating Packed Bed with Viscous Newtonian and Non-Newtonian Fluids” Industrial & Engineering Chemistry Research 44(4), 1043-1051 (2005) (SCI, EI)

10. S. S. Wang, C. K. Chang, and H. S. Liu “Step Change of Mobile Phase Flow Rates to Enhance Protein Folding in Size Exclusion Chromatography “, Biochemical Engineering J. 29, 2–11 (2006) (SCI, EI) ( 合著 )

11. S. S. Wang, C.K. Chang, and H S. Liu “Effect of Glutathione Redox System on Protein Refolding in Size Exclusion Chromatography” Trans IChemE, Part C, Food and Bioproducts Processin g, 84: 18–27 (2006) (SCI, EI) ( 合著 )

12. Y. S. Chen, C.T. Tai, M. H. Chang, and H. S. Liu “Characteristics of Micromixing in a Rotating Packed Bed” J. Chin. Inst. Chem. Engrs. 37(1), 63-69 (2006) (SCI, EI)

13. C. Y. Tai, C. T. Tai and H. S. Liu “Synthesis of submicron barium carbonate using a high-gravity technique” Chemical Engineering Science 61:7479 – 7486 (2006) (SCI, EI) ( 合著 )

14. Y. S. Chen, F. Y. Lin, C. C. Lin , C. Y. D. Tai and H. S. Liu “Packing Characteristics for Mass Transfer in a Rotating Packed Bed” Industrial & Engineering Chemistry Research 45: 6846-6853 (2006) (SCI, EI) ( 合著 )

15. L. A. Sayavedra-Soto, W. N. Chang, T. K. Lin, C. L. Ho and H. S. Liu “Alkane utilization by Rhodococcus strain NTU-1 alone and in its natural association with Bacillus fusiformis L-1 and Ochrobactrum sp.” Biotechnology Progress, 22, 1368-1373 (2006) (SCI, EI)

16. S. S. Wang, C. K. Chang and H. S. Liu “Effect of sample loop dimension on lysozyme refolding in size-exclusion chromatography” J. Chromatography A . 1161: 56-63 (2007) (SCI, EI) ( 合著 )

17. S. C. Wu, S. H. Shih and H. S. Liu “Dynamic behavior of double-substrate interactive model” J. Chin. Inst. Chem. Engrs. 38, 107–115 (2007) (SCI, EI)

18. C. Y. Tai, C. T. Tai, M. H. Chang, and H. S. Liu “Synthesis of Magnesium Hydroxide and Oxide Nanoparticles Using a Spinning Disk Reactor” Industrial & Engineering Chemistry Research , 46, 5536-5541 (2007) (SCI, EI) ( 合著 )

19. S. S. S. Wang, J. W. Wu, S. Yamamoto, and H. S. Liu “Diseases of Protein Aggregation and the Hunt for Potential Pharmacological Agents” Biotechnology Journal (in press) (2007) (EI) ( 合著 )

20. C. Y. Tai, Y. H. Wang, and H. S. Liu “A Green Process for Preparing Silver Nanoparticles Using Spinning Disk Reactor” AIChE J. (accepted 2007) (SCI, EI) ( 合著 )