研究主題

生化程序工程
本實驗室著重生化程序工程及其相關領域研究，其包括生化反應及分離技術。在反應技術部份曾有再生資源的生化轉換、油污生物降解、週期式操作及相關動態行為、醱酵即時抑制物移除、昆蟲細胞與桿狀病毒系統生產藥用蛋白、無血清培養基、添加劑增加氧氣傳遞及提昇產量、及異澱粉酵素之應用(固定化技術、超臨界流體下之反應)。在下游程序則包含蛋白質／酵素分離技術(吸附、層析、泡沫分離)，蛋白質穩定性與復性。

超重力系統
超重力系統(旋轉填充床)可大幅提高質傳效果，進而縮小系統設備。本實驗室已成功應用於吸收氣提吸附等單元操作， 同時設計基礎研究亦在進行中。

最新研究

 1.以大小排阻層析法進行蛋白質復性之研究(3/3)
 
2.綠色化學程序」尖端技術科專計劃 第二期(3/3)

榮譽獎項

代表著作 近五年著作

1. S. C. Wu, S. H. Shih and H. S. Liu “Dynamic behavior of double-substrate interactive model” J. Tw. Inst. Chem. Engrs. 38, 107–115 (2007) (SCI, EI)

2. C. Y. Tai, C. T. Tai, M. H. Chang, and H. S. Liu “Synthesis of Magnesium Hydroxide and Oxide Nanoparticles Using a Spinning Disk Reactor” Industrial & Engineering Chemistry Research, 46, 5536-5541 (2007) (SCI, EI)

3. S. S. S. Wang, J. W. Wu, S. Yamamoto, and H. S. Liu “Diseases of Protein Aggregation and the Hunt for Potential Pharmacological Agents” Biotechnology Journal 3, 165-192 (2008) (合著)

4. C. Y. Tai, Y. H. Wang, and H. S. Liu, “A green process for preparing silver nanoparticles using spinning disk reactor” AIChE J., 54(2), 445-452 (2008) (SCI, EI)

5. Y. C. Lee, H. S. Liu, S. Y. Lin, H. F. Huang, Y. Y. Wang, and L. W. Chou “An observation of the coexistence of multimers and micelles in a nonionic surfactant C10E4 solution by dynamic light scattering” J. Tw. Inst. Chem. Engrs. 39, 75–83 (2008) (SCI, EI)

6. Y. S. Chen, Y. C. Hsu, C. C. Lin, C. Y. Tai, and H. S. Liu “VOC Absorption in a Cross-Flow Rotating Packed Bed” Environmental Science & Technology, 42, 2631-2636 (2008) (SCI, EI)

7. C. Y. Tai, Y. H. Wang, C. T. Tai, H. S. Liu “Preparation of Silver Nanoparticles Using SDR in a Continuous Mode” Industrial & Engineering Chemistry Research 48, 10104 - 10109 (2009) (SCI, EI)

8. W. N. Chang, C. W. Liu, and H. S. Liu “Hydrophobic Cell Surface and Bioflocculation Behavior of Rhodococcus erythropolis Sea Water” Process Biochemistry 44, 955-962 (2009) (SCI, EI)

9. C. Y. Tai, Y. H. Wang, Y. W. Kuo, M. H. Chang, H. S. Liu “Synthesis of silver particles below 10nm using spinning disk reactor” Chemical Engineering Science 64, 3112 – 3119 (2009) (SCI, EI)

10. C. W Liu, W. N. Chang, and H. S. Liu “Bioremediation of n-alkanes and the Formation of Biofloccules by Rhodococcus erythropolis NTU-1 under Various Saline Conditions and Sea Water”, Biochem. Eng. J. 45, 69–75 (2009) (SCI, EI)

11. S. S. S. Wang, H. S. Chao, H. L. Liu, and H. S. Liu “Stability of Hen Egg White Lysozyme during Denaturation is enhanced via Pretreatment in Supercritical Carbon Dioxide” Journal of Bioscience and Bioengineering 107, 355-359 (2009) (SCI, EI) (合著)

12. E. J. Hsu, J. F. Hsu, S. L. Landuyt, H. S. Chao and H. S. Liu, “Semi-Continuous Propagation and Synchronous Differentiation of Hyper-Solventogenic Cells of Clostridium thermosaccharolyticum in a Xylan Medium at 56oC” J. Tw. Inst. Chem. Engrs. 40, 349-358 (2009) (SCI, EI)

13. C. Y. Chiang, Y. S. Chen, M. S. Liang, F. Y. Lin, C. Y. D. Tai and H. S. Liu “Absorption of Ethanol into Water and Glycerol/Water Solution in a Rotating Packed Bed” J. Tw. Inst. Chem. Engrs. 40, 418-423 (2009)(SCI, EI)

14. S. S. S. Wang, J. T. Lai, M. S. Huang, C. Y. Tai, and H. S. Liu “Deactivation of isoamylase and beta-amylase in the agitated reactor under supercritical carbon dioxide” Bioprocess Biosyst Eng, 33, 1007-1015 (2010) (SCI, EI) (合著)

15. Y. S. Chen, Y. H. Wang, H. S. Liu, K. Y. Hsu, and C. Y. Tai “Micronization of p-Aminosalicylic Acid Particles Using High-Gravity Technique” Industrial & Engineering Chemistry Research 49, 8832-8840 (2010) (SCI, EI)

16. C. W. Liu, and H. S. Liu “Rhodococcus erythropolis strain NTU-1 efficiently degrades and traps diesel and crude oil in batch and fed-batch bioreactors” Process Biochemistry 46, 202-209 (2011) (SCI, EI)

17. Y. C. Chen and H. S. Liu “Considerations of chaperon solvent plug design in protein refolding by size-exclusion chromatography” Enzy. Mircrob. Tech. 49, 203-208 (2011) (SCI, EI)

18. M. H. Chang, H. S. Liu, and C. Y. Tai, “Preparation of Copper Oxide Nanoparticles and Its Application In Nanofluid” Powder Technology 207, 378–386 (2011) (SCI, EI)

19. H. S. Liu, Y. H. Wang, C. C. Li and C.Y. Tai “Characterization of AgI nanoparticles synthesized in a spinning disk reactor” Chem. Eng. J. (accepted) (SCI, EI)

20. C. W. Liu, M. S. Liang, Y. C. Chen, L. Sayavedra-Soto and H. S. Liu “Biodegradation of n-alkanes at high concentration and correlation to the accumulation of H+ ions in Rhodococcus erythropolis NTU-1” Biochem. Eng. J. (accepted) (SCI, EI)