- Education Background
B.S. Ch.E. National Taiwan University, 1989
M.S. Biochemistry National Taiwan University, 1991
Ph. D. Bioengineering University of Washington, 1999
- Research Topic
Surface modification of biomaterials for improvement in biocompatibility: development of new surface modification techniques to enhance biomaterials’ biocompatibility with respect to cell affinity or anti-fouling ability.
Cell responses to surface topographies: investigation of the effects of surface micro-/nano-metric topographies on cell morphology, adhesion, growth and differentiation in order to control cell behaviors and apply to tissue engineering.
Biomaterial development for tissue engineering applications: development of scaffolds in the form of hydrogels or nanofibers, that are incorporated with active biomolecules for cell growth and differentiation.
- Recent Research Topic
1. 紡織產業卓越創新研究中心業務推展 NT$ 450,000, 紡織研究所, 03/01/2008-12/31/2008
2. 製備具有微圖樣的聚電解質多層膜及其在細胞工程的應用 NT$ 970,000, 97-2628-E-002-028-MY2, 08/01/2008-07/31/2009
- The Representative Publication Recent 5-years Publication
- Chiao-Tzu Su, Ruei-Hung Yuan, Yung-Chih Chen, Ting-Ju Lin, Hsiu-Wen Chien, Chih-Chen Hsieh, Wei-Bor Tsai, Chih-Hao Chang, Hsien-Yeh Chen. A Facile Approach toward Protein-Resistant Biointerfaces Based on Photodefinable Poly-pxylylene Coating. Colloids and surfaces B, 116: 727–733, 2014. (SCI, EI) (合著)
- Cindy Yi Chi Hsieh, Fang-Wei Hu, Wen-Shiang Chen, Wei-Bor Tsai*. Reducing the foreign body reaction by surface modification with collagen/hyaluronic acid multilayered films. ISRN Biomaterials, 2014, Article ID 718432, 2014.
- Chia-Wen Lo, Yung Chang, Jyun-Lin Lee, Wei-Bor Tsai, Wen-Shiang Chen. Tertiary-amine functionalized polyplexes enhanced cellular uptake and prolonged gene expression. PLoS ONE. 9(5):e97627, 2014. (SCI)
- Wei-Bor Tsai*, Hsin-Yu Lai, Jyun-Lin Lee, Chia-Wen Lo, Wen-Shiang Chen. Enhancement of the cytotoxicity and selectivity of doxorubicin to hepatoma cells by synergistic combination of galactose-decorated gamma-poly(glutamic acid) nanoparticles and low-intensity ultrasound. Langmuir, 30(19):5510-5517, 2014. (SCI, EI)
- Jiashing Yu, An-Rei Lee, Wei-Han Lin, Che-Wei Lin, Yuan Kun Wu, Wei-Bor Tsai*. Electrospun PLGA fibers incorporated with functionalized biomolecules for cardiac tissue engineering. Tissue Engineering Part A, 20(13-14):1896-1907, 2014. (SCI, EI) (合著)
- Hsiu-Wen Chien, Ming-Chun Keng, Meng-Jiy Wang, Hsien-Yeh Chen, Sheng-Tung Huang, Wei-Bor Tsai*, Conjugation of mono-carboxybetaine molecules on amino-poly-p-xylylenes films to reduce protein adsorption and cell adhesion. Langmuir, 30:14257−14262, 2014. (SCI, EI) (合著)
- Jiashing Yu, Jeng-Chun Mei, Yuan Kun Wu, Po-Chen Wu, Wei-Bor Tsai, Nai-Chen Cheng. 3D extracellular matrix scaffolds by microfluidic fabrication for long-term spontaneously contracted cardiomyocytes culture. Tissue Engineering Part A, 20(21-22): 2931-2941, 2014. (SCI, EI) (合著)
- Hsiu-Wen Chien, Szu-Wei Fu, Ai-Yun Shih and Wei-Bor Tsai*. Modulation of the stemness and osteogenic differentiation of human mesenchymal stem cells by controlling RGD concentrations of poly(carboxybetaine) hydrogel. Biotechnology Journal, 9(12):1613-23, 2014. (SCI, EI)
- Chih-Yeh Lin, Yi-Ren Wang, Che-Wei Lin, Shih-Wen Wang, Hsiu-Wen Chien, Nai-Chen Cheng, Wei-Bor Tsai, and Jiashing Yu, Peptide-modified zwitterionic porous hydrogels for endothelial cell and vascular engineering. BioResearch Open Access, 3(6):297-310, 2014. (合著)
- Peng-Yuan Wang, Lauren R. Clements, Helmut Thissen, Wei-Bor Tsai, Nicolas H. Voelcker. Screening rat mesenchymal stem cell attachment and differentiation on surface chemistries using plasma polymer gradients, Acta Biomaterialia, 11:58–67, 2015. (SCI, EI)
- Chia-Wen Lo, Wei-Hao Liao, Chueh-Hung Wu, Jyun-Lin Lee, Ming-Kuan Sun, Hui-Shan Yang, Wei-Bor Tsai, Yung Chang, Wen-Shiang Chen. Synergistic Effect of PEI and PDMAEMA on Transgene Expression in Vitro, Langmuir, 31(22): 6130-6136, 2015.
- Hsiu-Wen Chien, Ming-Chun Keng, Hsien-Yeh Chen, Sheng-Tung Huang and Wei-Bor Tsai*. “Conjugation of mono-sulfobetaine to alkyne-PPX films via click reaction to reduce cell adhesion”, Biomaterials and Biomechanics in Bioengineering, 3: 59-69, 2015. (合著)
- Wei-Han Lin, Jiashing Yu, Guoping Chen, Wei-Bor Tsai*. “Fabrication of multi-biofunctional gelatin-based electrospun fibrousscaffolds for enhancement of osteogenesis of mesenchymal stem cells”, Colloids and Surfaces B: Biointerfaces, 138:26–31, 2016. (合著)
- T. C. Lai, J. Yu* and W. B. Tsai*. “Gelatin methacrylate/carboxybetaine methacrylate hydrogels with tunable crosslinking for controlled drug release”, J. Mater. Chem. B, 4:2304-2313, 2016. (合著)
- H.W. Chien, P.H. Cheng, S.Y. Chen, J Yu*, W.B. Tsai*. “Low-fouling and functional poly(carboxybetaine) coating via a photo-crosslinking process.” Biomaterials Science, 5:523-531 2017. (合著)
- H.W. Chien, J Yu*, S.T. Li, H.Y. Chen, W.B. Tsai.* “An in situ poly(carboxybetaine) hydrogel for tissue engineering applications.” Biomaterials Science, 5(2):322-330, 2017. (合著)
- I.N. Ahmed, R. Chang, W.B. Tsai.* “Poly(acrylic acid) nanogel as a substrate for cellulase immobilization for hydrolysis of cellulose”, Colloids and Surfaces B: Biointerfaces, 152:339-343, 2017.
- P.Y. Wang, Y.L. Lian, R. Chang, W.H. Liao, W.S. Chen, and W.B. Tsai.* “Modulation of PEI-Mediated Gene Transfection through Controlling Cytoskeleton Organization and Nuclear Morphology via Nanogrooved Topographies.” ACS Biomater. Sci. Eng., 3(12):3283–3291, 2017.
- Pei-Ru Chen, Ting-Ching Wang, Shih-Ting Chen, Hsien-Yeh Chen, Wei-Bor Tsai.* “Development of Antifouling Hyperbranched Polyglycerol Layers on Hydroxyl Poly-p-xylylene Coatings”, Langmuir, 33:14657–14662, 2017. (合著)
- Min Lu, Yi Liu, Yung-Chi Huang, Chun-Jen Huang, Wei-Bor Tsai*, “Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive” Carbohydrate Polymers, 181: 1026-1032, 2018.