Wei-Bor Tsai Professor

Wei-Bor Tsai Professor
蔡偉博 教授
email: WeiborTsai@ntu.edu.tw
office:Tseng Jiang Hall(N)N406
Lab Info
Biomaterials Laboratory
Tseng Jiang Hall(N)N401
  • Education Background

B.S. Ch.E. National Taiwan University, 1989
M.S. Biochemistry National Taiwan University, 1991
Ph. D. Bioengineering University of Washington, 1999

  • Research Topic

Surface modification of biomaterials for improvement in biocompatibility: development of new surface modification techniques to enhance biomaterials’ biocompatibility with respect to cell affinity or anti-fouling ability.

Cell responses to surface topographies: investigation of the effects of surface micro-/nano-metric topographies on cell morphology, adhesion, growth and differentiation in order to control cell behaviors and apply to tissue engineering.

Biomaterial development for tissue engineering applications: development of scaffolds in the form of hydrogels or nanofibers, that are incorporated with active biomolecules for cell growth and differentiation.

  • Recent Research Topic

1. 紡織產業卓越創新研究中心業務推展 NT$ 450,000, 紡織研究所, 03/01/2008-12/31/2008
2. 製備具有微圖樣的聚電解質多層膜及其在細胞工程的應用 NT$ 970,000, 97-2628-E-002-028-MY2, 08/01/2008-07/31/2009

  1. I. N. Ahmed, R. Chang and W. B. Tsai, “Poly(acrylic acid) nanogel as a substrate for cellulase immobilization for hydrolysis of cellulose”, Colloid Surface B 152, 339-343, (2017)
  2. P. R. Chen, T. C. Wang, S. T. Chen, H. Y. Chen and W. B. Tsai, “Development of Antifouling Hyperbranched Polyglycerol Layers on Hydroxyl Poly-p-xylylene Coatings”, Langmuir 33, 14657-14662, (2017)
  3. H. W. Chien, P. H. Cheng, S. Y. Chen, J. S. Yu and W. B. Tsai, “Low-fouling and functional poly(carboxybetaine) coating via a photo-crosslinking process”, Biomater Sci-Uk 5, 523-531, (2017)
  4. H. W. Chien, J. S. Yu, S. T. Li, H. Y. Chen and W. B. Tsai, “An in situ poly(carboxybetaine) hydrogel for tissue engineering applications”, Biomater Sci-Uk 5, 322-330, (2017)
  5. Y. Long, W. B. Tsai, D. J. Wang, D. H. Hawke, N. Savaraj, L. G. Feun, M. C. Hung, H. H. W. Chen and M. T. Kuo, “Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy”, Cancer Lett 388, 54-63, (2017)
  6. S. S. Nievethitha, N. Subhapradha, D. Saravanan, N. Selvamurugan, W. B. Tsai, N. Srinivasan, R. Murugesan and A. Moorthi, “Nanoceramics on osteoblast proliferation and differentiation in bone tissue engineering”, Int J Biol Macromol 98, 67-74, (2017)
  7. W. B. Tsai, Y. Long, J. T. Chang, N. Savaraj, L. G. Feun, M. Jung, H. H. W. Chen and M. T. Kuo, “Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1 alpha Degradation at the ASS1 promoter for ASS1 Derepression”, Sci Rep-Uk 7, (2017)
  8. P. Y. Wang, Y. S. Lian, R. Chang, W. H. Liao, W. S. Chen and W. B. Tsai, “Modulation of PEI-Mediated Gene Transfection through Controlling Cytoskeleton Organization and Nuclear Morphology via Nanogrooved Topographies”, Acs Biomater Sci Eng 3, 3283-3291, (2017)
  9. R. Chang, C. F. Hsu and W. B. Tsai, “Fabrication of Chlorophyll-Incorporated Nanogels for Potential Applications in Photothermal Cancer Therapy”, Acs Omega 3, 16057-16062, (2018)
  10. R. Chang and W. B. Tsai, “Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy”, Polymers-Basel 10, (2018)
  11. C. W. Lin, K. C. Yang, N. C. Cheng, W. B. Tsai, K. L. Lou and J. S. Yu, “Evaluation of adhesion, proliferation, and differentiation of human adipose-derived stem cells on keratin”, J Polym Res 25, (2018)
  12. W. H. Lin, C. Y. Lin, C. C. Tsai, J. S. Yu and W. B. Tsai, “Spheroid Formation of Human Adipose-Derived Stem Cells on Environmentally Friendly BMA/SBMA/HEMA Copolymer-Coated Anti-Adhesive Surface”, B Chem Soc Jpn 91, 1457-1464, (2018)
  13. M. Lu, Y. Liu, Y. C. Huang, C. J. Huang and W. B. Tsai, “Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive”, Carbohyd Polym 181, 668-674, (2018)
  14. S. K. Rajendrakumar, N. C. Chang, A. Mohapatra, S. Uthaman, B. I. Lee, W. B. Tsai and I. K. Park, “A Lipophilic IR-780 Dye-Encapsulated Zwitterionic Polymer-Lipid Micellar Nanoparticle for Enhanced Photothermal Therapy and NIR-Based Fluorescence Imaging in a Cervical Tumor Mouse Model”, Int J Mol Sci 19, (2018)
  15. Y. J. Yang, X. L. Wang, T. C. Huang, X. H. Hu, N. Kawazoe, W. B. Tsai, Y. N. Yang and G. P. Chen, “Regulation of mesenchymal stem cell functions by micro-nano hybrid patterned surfaces”, J Mater Chem B 6, 5424-5434, (2018)
  16. I. N. Ahmed, R. Chang, M. C. Keng, H. W. Chien, H. Y. Chen and W. B. Tsai, “Immobilization of functional polymers on poly(4-benzoyl-pxylylene-co-p-xylylene) films via photochemical conjugation for modulation of cell adhesion”, Colloid Surface B 174, 360-366, (2019)
  17. W. H. Chen, T. Y. Liao, H. Thissen and W. B. Tsai, “One-Step Aminomalononitrile-Based Coatings Containing Zwitterionic Copolymers for the Reduction of Biofouling and the Foreign Body Response”, Acs Biomater Sci Eng 5, 6454-6462, (2019)
  18. Q. H. Cui, T. H. Le, Y. J. Lin, Y. B. Miao, I. T. Sung, W. B. Tsai, H. Y. Chan, Z. H. Lin and H. W. Sung, “A self-powered battery-driven drug delivery device that can function as a micromotor and galvanically actuate localized payload release”, Nano Energy 66, (2019)
  19. Y. Liu, S. C. Ng, J. S. Yu and W. B. Tsai, “Modification and crosslinking of gelatin-based biomaterials as tissue adhesives”, Colloid Surface B 174, 316-323, (2019)
  20. P. T. Wu, C. L. Lin, C. W. Lin, N. C. Chang, W. B. Tsai and J. S. Yu, “Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells”, Nanomaterials-Basel 9, (2019)