
蔡偉博 教授
Wei-Bor Tsai
電話(02)3366-3996
傳真(02)23623040
電子郵件 WeiborTsai@ntu.edu.tw
辦公室:化工二館(鄭江樓北棟)N406
研究室資料
生醫材料研究室
化工二館(鄭江樓北棟)N401
(02)3366-3042
- 學經歷
台灣大學 化工學士,1989
台灣大學 生化碩士,1991
美國華盛頓大學 生物工程博士,1999
- 研究主題
生醫材料表面改質以增進生物相容性:開發新式的表面修飾技術,以提高生醫材料的生物相容性,聚焦於增進材料表面的細胞親和性或抗垢性。
細胞對於材料表面地形的反應:研究材料表面的微/奈米地形,對於細胞形態、貼附、生長與分化的影響,以調控細胞行為及應用於組織工程。
開發用於組織工程的生醫材料:開發添加生物活性分子,以水膠或奈米電紡絲的形式為主的支架,促進細胞生長及分化。
- 最新研究
1.紡織產業卓越創新研究中心業務推展 NT$ 400,000, 紡織研究所, 04/01/2009-12/31/2009
2.製備具有微圖樣的聚電解質多層膜及其在細胞工程的應用 NT$ 970,000, 97-2628-E-002-028-MY2, 08/01/2009-07/31/2010
- 榮譽獎項
- 代表著作 近五年著作
- I. N. Ahmed, R. Chang and W. B. Tsai, “Poly(acrylic acid) nanogel as a substrate for cellulase immobilization for hydrolysis of cellulose”, Colloid Surface B 152, 339-343, (2017)
- P. R. Chen, T. C. Wang, S. T. Chen, H. Y. Chen and W. B. Tsai, “Development of Antifouling Hyperbranched Polyglycerol Layers on Hydroxyl Poly-p-xylylene Coatings”, Langmuir 33, 14657-14662, (2017)
- H. W. Chien, P. H. Cheng, S. Y. Chen, J. S. Yu and W. B. Tsai, “Low-fouling and functional poly(carboxybetaine) coating via a photo-crosslinking process”, Biomater Sci-Uk 5, 523-531, (2017)
- H. W. Chien, J. S. Yu, S. T. Li, H. Y. Chen and W. B. Tsai, “An in situ poly(carboxybetaine) hydrogel for tissue engineering applications”, Biomater Sci-Uk 5, 322-330, (2017)
- Y. Long, W. B. Tsai, D. J. Wang, D. H. Hawke, N. Savaraj, L. G. Feun, M. C. Hung, H. H. W. Chen and M. T. Kuo, “Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy”, Cancer Lett 388, 54-63, (2017)
- S. S. Nievethitha, N. Subhapradha, D. Saravanan, N. Selvamurugan, W. B. Tsai, N. Srinivasan, R. Murugesan and A. Moorthi, “Nanoceramics on osteoblast proliferation and differentiation in bone tissue engineering”, Int J Biol Macromol 98, 67-74, (2017)
- W. B. Tsai, Y. Long, J. T. Chang, N. Savaraj, L. G. Feun, M. Jung, H. H. W. Chen and M. T. Kuo, “Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1 alpha Degradation at the ASS1 promoter for ASS1 Derepression”, Sci Rep-Uk 7, (2017)
- P. Y. Wang, Y. S. Lian, R. Chang, W. H. Liao, W. S. Chen and W. B. Tsai, “Modulation of PEI-Mediated Gene Transfection through Controlling Cytoskeleton Organization and Nuclear Morphology via Nanogrooved Topographies”, Acs Biomater Sci Eng 3, 3283-3291, (2017)
- R. Chang, C. F. Hsu and W. B. Tsai, “Fabrication of Chlorophyll-Incorporated Nanogels for Potential Applications in Photothermal Cancer Therapy”, Acs Omega 3, 16057-16062, (2018)
- R. Chang and W. B. Tsai, “Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy”, Polymers-Basel 10, (2018)
- C. W. Lin, K. C. Yang, N. C. Cheng, W. B. Tsai, K. L. Lou and J. S. Yu, “Evaluation of adhesion, proliferation, and differentiation of human adipose-derived stem cells on keratin”, J Polym Res 25, (2018)
- W. H. Lin, C. Y. Lin, C. C. Tsai, J. S. Yu and W. B. Tsai, “Spheroid Formation of Human Adipose-Derived Stem Cells on Environmentally Friendly BMA/SBMA/HEMA Copolymer-Coated Anti-Adhesive Surface”, B Chem Soc Jpn 91, 1457-1464, (2018)
- M. Lu, Y. Liu, Y. C. Huang, C. J. Huang and W. B. Tsai, “Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive”, Carbohyd Polym 181, 668-674, (2018)
- S. K. Rajendrakumar, N. C. Chang, A. Mohapatra, S. Uthaman, B. I. Lee, W. B. Tsai and I. K. Park, “A Lipophilic IR-780 Dye-Encapsulated Zwitterionic Polymer-Lipid Micellar Nanoparticle for Enhanced Photothermal Therapy and NIR-Based Fluorescence Imaging in a Cervical Tumor Mouse Model”, Int J Mol Sci 19, (2018)
- Y. J. Yang, X. L. Wang, T. C. Huang, X. H. Hu, N. Kawazoe, W. B. Tsai, Y. N. Yang and G. P. Chen, “Regulation of mesenchymal stem cell functions by micro-nano hybrid patterned surfaces”, J Mater Chem B 6, 5424-5434, (2018)
- I. N. Ahmed, R. Chang, M. C. Keng, H. W. Chien, H. Y. Chen and W. B. Tsai, “Immobilization of functional polymers on poly(4-benzoyl-pxylylene-co-p-xylylene) films via photochemical conjugation for modulation of cell adhesion”, Colloid Surface B 174, 360-366, (2019)
- W. H. Chen, T. Y. Liao, H. Thissen and W. B. Tsai, “One-Step Aminomalononitrile-Based Coatings Containing Zwitterionic Copolymers for the Reduction of Biofouling and the Foreign Body Response”, Acs Biomater Sci Eng 5, 6454-6462, (2019)
- Q. H. Cui, T. H. Le, Y. J. Lin, Y. B. Miao, I. T. Sung, W. B. Tsai, H. Y. Chan, Z. H. Lin and H. W. Sung, “A self-powered battery-driven drug delivery device that can function as a micromotor and galvanically actuate localized payload release”, Nano Energy 66, (2019)
- Y. Liu, S. C. Ng, J. S. Yu and W. B. Tsai, “Modification and crosslinking of gelatin-based biomaterials as tissue adhesives”, Colloid Surface B 174, 316-323, (2019)
- P. T. Wu, C. L. Lin, C. W. Lin, N. C. Chang, W. B. Tsai and J. S. Yu, “Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells”, Nanomaterials-Basel 9, (2019)