蔡偉博 教授(副系主任) / Wei-Bor Tsai Professor

• 學經歷

台灣大學　 　化工學士，1989
台灣大學　 　生化碩士，1991
美國華盛頓大學　生物工程博士，1999

• 研究主題

生醫材料表面改質以增進生物相容性：開發新式的表面修飾技術，以提高生醫材料的生物相容性，聚焦於增進材料表面的細胞親和性或抗垢性。

細胞對於材料表面地形的反應：研究材料表面的微/奈米地形，對於細胞形態、貼附、生長與分化的影響，以調控細胞行為及應用於組織工程。

開發用於組織工程的生醫材料：開發添加生物活性分子，以水膠或奈米電紡絲的形式為主的支架，促進細胞生長及分化。

• 最新研究

1.紡織產業卓越創新研究中心業務推展 NT$ 400,000, 紡織研究所, 04/01/2009-12/31/2009

2.製備具有微圖樣的聚電解質多層膜及其在細胞工程的應用 NT$ 970,000, 97-2628-E-002-028-MY2, 08/01/2009-07/31/2010

• 榮譽獎項
• 代表著作 近五年著作

1. Chiao-Tzu Su, Ruei-Hung Yuan, Yung-Chih Chen, Ting-Ju Lin, Hsiu-Wen Chien, Chih-Chen Hsieh, Wei-Bor Tsai, Chih-Hao Chang, Hsien-Yeh Chen. A Facile Approach toward Protein-Resistant Biointerfaces Based on Photodefinable Poly-pxylylene Coating. Colloids and surfaces B, 116: 727–733, 2014. (SCI, EI) (合著)
2. Cindy Yi Chi Hsieh, Fang-Wei Hu, Wen-Shiang Chen, Wei-Bor Tsai*. Reducing the foreign body reaction by surface modification with collagen/hyaluronic acid multilayered films. ISRN Biomaterials, 2014, Article ID 718432, 2014.
3. Chia-Wen Lo, Yung Chang, Jyun-Lin Lee, Wei-Bor Tsai, Wen-Shiang Chen. Tertiary-amine functionalized polyplexes enhanced cellular uptake and prolonged gene expression. PLoS ONE. 9(5):e97627, 2014. (SCI)
4. Wei-Bor Tsai*, Hsin-Yu Lai, Jyun-Lin Lee, Chia-Wen Lo, Wen-Shiang Chen. Enhancement of the cytotoxicity and selectivity of doxorubicin to hepatoma cells by synergistic combination of galactose-decorated gamma-poly(glutamic acid) nanoparticles and low-intensity ultrasound. Langmuir, 30(19):5510-5517, 2014. (SCI, EI)
5. Jiashing Yu, An-Rei Lee, Wei-Han Lin, Che-Wei Lin, Yuan Kun Wu, Wei-Bor Tsai*. Electrospun PLGA fibers incorporated with functionalized biomolecules for cardiac tissue engineering. Tissue Engineering Part A, 20(13-14):1896-1907, 2014. (SCI, EI) (合著)
6. Hsiu-Wen Chien, Ming-Chun Keng, Meng-Jiy Wang, Hsien-Yeh Chen, Sheng-Tung Huang, Wei-Bor Tsai*, Conjugation of mono-carboxybetaine molecules on amino-poly-p-xylylenes films to reduce protein adsorption and cell adhesion. Langmuir, 30:14257−14262, 2014. (SCI, EI) (合著)
7. Jiashing Yu, Jeng-Chun Mei, Yuan Kun Wu, Po-Chen Wu, Wei-Bor Tsai, Nai-Chen Cheng. 3D extracellular matrix scaffolds by microfluidic fabrication for long-term spontaneously contracted cardiomyocytes culture. Tissue Engineering Part A, 20(21-22): 2931-2941, 2014. (SCI, EI) (合著)
8. Hsiu-Wen Chien, Szu-Wei Fu, Ai-Yun Shih and Wei-Bor Tsai*. Modulation of the stemness and osteogenic differentiation of human mesenchymal stem cells by controlling RGD concentrations of poly(carboxybetaine) hydrogel. Biotechnology Journal, 9(12):1613-23, 2014. (SCI, EI)
9. Chih-Yeh Lin, Yi-Ren Wang, Che-Wei Lin, Shih-Wen Wang, Hsiu-Wen Chien, Nai-Chen Cheng, Wei-Bor Tsai, and Jiashing Yu, Peptide-modified zwitterionic porous hydrogels for endothelial cell and vascular engineering. BioResearch Open Access, 3(6):297-310, 2014. (合著)
10. Peng-Yuan Wang, Lauren R. Clements, Helmut Thissen, Wei-Bor Tsai, Nicolas H. Voelcker. Screening rat mesenchymal stem cell attachment and differentiation on surface chemistries using plasma polymer gradients, Acta Biomaterialia, 11:58–67, 2015. (SCI, EI)
11. Chia-Wen Lo, Wei-Hao Liao, Chueh-Hung Wu, Jyun-Lin Lee, Ming-Kuan Sun, Hui-Shan Yang, Wei-Bor Tsai, Yung Chang, Wen-Shiang Chen. Synergistic Effect of PEI and PDMAEMA on Transgene Expression in Vitro, Langmuir, 31(22): 6130-6136, 2015.
12. Hsiu-Wen Chien, Ming-Chun Keng, Hsien-Yeh Chen, Sheng-Tung Huang and Wei-Bor Tsai*. “Conjugation of mono-sulfobetaine to alkyne-PPX films via click reaction to reduce cell adhesion”, Biomaterials and Biomechanics in Bioengineering, 3: 59-69, 2015. (合著)
13. Wei-Han Lin, Jiashing Yu, Guoping Chen, Wei-Bor Tsai*. “Fabrication of multi-biofunctional gelatin-based electrospun fibrousscaffolds for enhancement of osteogenesis of mesenchymal stem cells”, Colloids and Surfaces B: Biointerfaces, 138:26–31, 2016. (合著)
14. T. C. Lai, J. Yu* and W. B. Tsai*. “Gelatin methacrylate/carboxybetaine methacrylate hydrogels with tunable crosslinking for controlled drug release”, J. Mater. Chem. B, 4:2304-2313, 2016. (合著)
15. H.W. Chien, P.H. Cheng, S.Y. Chen, J Yu*, W.B. Tsai*. “Low-fouling and functional poly(carboxybetaine) coating via a photo-crosslinking process.” Biomaterials Science, 5:523-531 2017. (合著)
16. H.W. Chien, J Yu*, S.T. Li, H.Y. Chen, W.B. Tsai.* “An in situ poly(carboxybetaine) hydrogel for tissue engineering applications.” Biomaterials Science, 5(2):322-330, 2017. (合著)
17. I.N. Ahmed, R. Chang, W.B. Tsai.* “Poly(acrylic acid) nanogel as a substrate for cellulase immobilization for hydrolysis of cellulose”, Colloids and Surfaces B: Biointerfaces, 152:339-343, 2017.
18. P.Y. Wang, Y.L. Lian, R. Chang, W.H. Liao, W.S. Chen, and W.B. Tsai.* “Modulation of PEI-Mediated Gene Transfection through Controlling Cytoskeleton Organization and Nuclear Morphology via Nanogrooved Topographies.” ACS Biomater. Sci. Eng., 3(12):3283–3291, 2017.
19. Pei-Ru Chen, Ting-Ching Wang, Shih-Ting Chen, Hsien-Yeh Chen, Wei-Bor Tsai.* “Development of Antifouling Hyperbranched Polyglycerol Layers on Hydroxyl Poly-p-xylylene Coatings”, Langmuir, 33:14657–14662, 2017. (合著)
20. Min Lu, Yi Liu, Yung-Chi Huang, Chun-Jen Huang, Wei-Bor Tsai*, “Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive” Carbohydrate Polymers, 181: 1026-1032, 2018.