蔡偉博 教授 / Wei-Bor Tsai Professor

Index
蔡偉博 教授
Wei-Bor Tsai
電話(02)3366-3996
傳真(02)23623040
電子郵件 WeiborTsai@ntu.edu.tw
辦公室:化工二館(鄭江樓北棟)N406
研究室資料
生醫材料研究室
化工二館(鄭江樓北棟)N401
(02)3366-3042
  • 學經歷

台灣大學　 　化工學士，1989
台灣大學　 　生化碩士，1991
美國華盛頓大學　生物工程博士，1999

  • 研究主題

生醫材料表面改質以增進生物相容性：開發新式的表面修飾技術，以提高生醫材料的生物相容性，聚焦於增進材料表面的細胞親和性或抗垢性。

細胞對於材料表面地形的反應：研究材料表面的微/奈米地形，對於細胞形態、貼附、生長與分化的影響，以調控細胞行為及應用於組織工程。

開發用於組織工程的生醫材料：開發添加生物活性分子，以水膠或奈米電紡絲的形式為主的支架，促進細胞生長及分化。

  • 最新研究

1.紡織產業卓越創新研究中心業務推展 NT$ 400,000, 紡織研究所, 04/01/2009-12/31/2009

2.製備具有微圖樣的聚電解質多層膜及其在細胞工程的應用 NT$ 970,000, 97-2628-E-002-028-MY2, 08/01/2009-07/31/2010

  1. I. N. Ahmed, R. Chang and W. B. Tsai, “Poly(acrylic acid) nanogel as a substrate for cellulase immobilization for hydrolysis of cellulose”, Colloid Surface B 152, 339-343, (2017)
  2. P. R. Chen, T. C. Wang, S. T. Chen, H. Y. Chen and W. B. Tsai, “Development of Antifouling Hyperbranched Polyglycerol Layers on Hydroxyl Poly-p-xylylene Coatings”, Langmuir 33, 14657-14662, (2017)
  3. H. W. Chien, P. H. Cheng, S. Y. Chen, J. S. Yu and W. B. Tsai, “Low-fouling and functional poly(carboxybetaine) coating via a photo-crosslinking process”, Biomater Sci-Uk 5, 523-531, (2017)
  4. H. W. Chien, J. S. Yu, S. T. Li, H. Y. Chen and W. B. Tsai, “An in situ poly(carboxybetaine) hydrogel for tissue engineering applications”, Biomater Sci-Uk 5, 322-330, (2017)
  5. Y. Long, W. B. Tsai, D. J. Wang, D. H. Hawke, N. Savaraj, L. G. Feun, M. C. Hung, H. H. W. Chen and M. T. Kuo, “Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy”, Cancer Lett 388, 54-63, (2017)
  6. S. S. Nievethitha, N. Subhapradha, D. Saravanan, N. Selvamurugan, W. B. Tsai, N. Srinivasan, R. Murugesan and A. Moorthi, “Nanoceramics on osteoblast proliferation and differentiation in bone tissue engineering”, Int J Biol Macromol 98, 67-74, (2017)
  7. W. B. Tsai, Y. Long, J. T. Chang, N. Savaraj, L. G. Feun, M. Jung, H. H. W. Chen and M. T. Kuo, “Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1 alpha Degradation at the ASS1 promoter for ASS1 Derepression”, Sci Rep-Uk 7, (2017)
  8. P. Y. Wang, Y. S. Lian, R. Chang, W. H. Liao, W. S. Chen and W. B. Tsai, “Modulation of PEI-Mediated Gene Transfection through Controlling Cytoskeleton Organization and Nuclear Morphology via Nanogrooved Topographies”, Acs Biomater Sci Eng 3, 3283-3291, (2017)
  9. R. Chang, C. F. Hsu and W. B. Tsai, “Fabrication of Chlorophyll-Incorporated Nanogels for Potential Applications in Photothermal Cancer Therapy”, Acs Omega 3, 16057-16062, (2018)
  10. R. Chang and W. B. Tsai, “Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy”, Polymers-Basel 10, (2018)
  11. C. W. Lin, K. C. Yang, N. C. Cheng, W. B. Tsai, K. L. Lou and J. S. Yu, “Evaluation of adhesion, proliferation, and differentiation of human adipose-derived stem cells on keratin”, J Polym Res 25, (2018)
  12. W. H. Lin, C. Y. Lin, C. C. Tsai, J. S. Yu and W. B. Tsai, “Spheroid Formation of Human Adipose-Derived Stem Cells on Environmentally Friendly BMA/SBMA/HEMA Copolymer-Coated Anti-Adhesive Surface”, B Chem Soc Jpn 91, 1457-1464, (2018)
  13. M. Lu, Y. Liu, Y. C. Huang, C. J. Huang and W. B. Tsai, “Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive”, Carbohyd Polym 181, 668-674, (2018)
  14. S. K. Rajendrakumar, N. C. Chang, A. Mohapatra, S. Uthaman, B. I. Lee, W. B. Tsai and I. K. Park, “A Lipophilic IR-780 Dye-Encapsulated Zwitterionic Polymer-Lipid Micellar Nanoparticle for Enhanced Photothermal Therapy and NIR-Based Fluorescence Imaging in a Cervical Tumor Mouse Model”, Int J Mol Sci 19, (2018)
  15. Y. J. Yang, X. L. Wang, T. C. Huang, X. H. Hu, N. Kawazoe, W. B. Tsai, Y. N. Yang and G. P. Chen, “Regulation of mesenchymal stem cell functions by micro-nano hybrid patterned surfaces”, J Mater Chem B 6, 5424-5434, (2018)
  16. I. N. Ahmed, R. Chang, M. C. Keng, H. W. Chien, H. Y. Chen and W. B. Tsai, “Immobilization of functional polymers on poly(4-benzoyl-pxylylene-co-p-xylylene) films via photochemical conjugation for modulation of cell adhesion”, Colloid Surface B 174, 360-366, (2019)
  17. W. H. Chen, T. Y. Liao, H. Thissen and W. B. Tsai, “One-Step Aminomalononitrile-Based Coatings Containing Zwitterionic Copolymers for the Reduction of Biofouling and the Foreign Body Response”, Acs Biomater Sci Eng 5, 6454-6462, (2019)
  18. Q. H. Cui, T. H. Le, Y. J. Lin, Y. B. Miao, I. T. Sung, W. B. Tsai, H. Y. Chan, Z. H. Lin and H. W. Sung, “A self-powered battery-driven drug delivery device that can function as a micromotor and galvanically actuate localized payload release”, Nano Energy 66, (2019)
  19. Y. Liu, S. C. Ng, J. S. Yu and W. B. Tsai, “Modification and crosslinking of gelatin-based biomaterials as tissue adhesives”, Colloid Surface B 174, 316-323, (2019)
  20. P. T. Wu, C. L. Lin, C. W. Lin, N. C. Chang, W. B. Tsai and J. S. Yu, “Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells”, Nanomaterials-Basel 9, (2019)