Ling Chao Associate Professor

Index
Ling Chao Associate Professor
趙 玲 副教授
phone:(02)3366-3023
email: lingchao@ntu.edu.tw
office:Tseng Jiang Hall(N)N412
Lab Info

Biomimetic Membrane Interfacial Phenomena and Engineering Lab

Tseng Jiang Hall(N)N411
(02)3366-9936
  • Education Background

B.S. Ch.E. National Taiwan University, 2003
Ph.D. Ch.E. Massachusetts Institute of Technology, 2009
Post doc. Cornell University, 2009-2011

  • Research Topic

Cell Membrane Mimic Bio-chips
Our research interest is to develop cell membrane mimic platforms to understand the underlying mechanisms of membrane related cellular processes for novel therapeutic applications. Cell membranes are the gateway for cells to send and receive signals and for pathogen infection. Membrane proteins are the primary drug targets; however, they are difficult to study, since their structures, functions, and activities are highly sensitive to their lipid membrane environments. Cell membrane mimic platforms allow these proteins to be studied in their native environments.

Phase Transformation and Transport Phenomena in Lipid Membranes
The phase dynamics and species transport in lipid membranes has been suggested to influence many cellular processes. Incorporating microfluidic and microfabriaction techniques, we can have control over lipid membrane’s pre-determined constituents, the spatial organization of membranes and proteins, and when different biomolecules interact with each other. The spatio-temporal control, which is difficult to achieve in conventional methods, allows us to obtain fundamental understanding of biomembrane related cellular processes and to discover new biophysical phenomena.

  • Recent Research Topic

Current research programs include:
Studying phase transformation phenomena in bio-membranes
Exploring physical pathway for potential therapeutic applications of phospholipase related disease.
Liposome based drug delivery application

Bio-interface engineering for studying peripheral protein-lipid membrane interactions
Use microfluidic and microfabrication techniques to develop composite membranes to study how the membrane catalyzes membrane protein structure changes
High throughput screening of environmental conditions in microfluidic devices

  • Honor
  1. 獲得傑出人才基金會頒發的年輕學者創新獎
  2. 獲得日本化學學會頒發的 “Lectureship Award 2017”
  3. 獲得科技部2016優秀年輕學者計畫
  4. 台灣化工學會2015年優秀年輕學者
  5. 台灣化工學會2015年化工傑作獎
  6. Lab on a chip 期刊封面+2014 熱門文章
  7. 指導林郁婷同學參與2016台灣化學工程學會六十三週年慶祝大會暨科技部化學工程學門成果發表會榮獲英文報告競賽優勝
  8. 指導呂紹瑋同學參與2016台灣化學工程學會六十三週年慶祝大會暨科技部化學工程學門成果發表會榮獲壁報論文競賽生化與生醫組優勝
  9. 指導蕭凱鴻同學參與2016台灣化學工程學會六十三週年慶祝大會暨科技部化學工程學門成果發表會榮獲壁報論文競賽輸送現象及其應用國際研討會組優勝
  10. 指導邱鈺婷同學參與2016台灣化學工程學會六十三週年慶祝大會暨科技部化學工程學門成果發表會榮獲壁報論文競賽熱力及界面工程組佳作
  11. 指導洪嘉怡同學參與2016年中華民國界面科學學會年會暨科技部化工學門成果發表會榮獲最佳論文優等獎
  12. 指導王柔方同學參與2016年中華民國界面科學學會年會暨科技部化工學門成果發表會榮獲壁報論文優等獎
  13. 指導胡書愷同學參與台灣化學工程學會六十二週年年會暨國科會化學工程學門成果發表會榮獲研究生英語專題報告競賽組佳作
  14. 指導胡書愷同學參與2015年台灣生物化學工程學會舉辦之生物科技和工程會議榮獲英文口頭報告競賽生物感測組第一名
  15. 指導郭政融同學參與台灣化學工程學會六十一週年年會暨國科會化學工程學門成果發表會榮獲壁報論文專題競賽熱力及界面工程組特優
  16. 指導杜育銘同學參與台灣化學工程學會六十一週年年會暨國科會化學工程學門成果發表會榮獲研究生英語專題報告競賽組佳作
  17. 指導蔣伯頡同學參與台灣化學工程學會六十一週年年會暨國科會化學工程學門成果發表會榮獲壁報論文專題競賽生化及生醫工程組佳作
  18. 指導杜育銘同學參與2014 International Symposium on Chemical Environmental Biomedical Technology (isCEBT)國際會議榮獲最佳口頭報告獎
  19. 指導韓宗達同學參與台灣化學工程學會六十週年年會暨國科會化學工程學門成果發表會榮獲壁報論文專題競賽研究生英語專題報告競賽組佳作
  20. 指導胡書愷同學參與台灣化學工程學會六十週年年會暨國科會化學工程學門成果發表會榮獲壁報論文專題競賽輸送現象及分離技術組佳作
  21. 指導林長育同學參與第十八屆生物物理研討會榮獲壁報及英語報告競賽第一名
  22. 指導林長育同學參與台灣化學工程學會五十九週年年會暨國科會化學工程學門成果發表會榮獲壁報論文專題競賽輸送現象及分離技術組佳作
  1. Po-Chieh Chiang, Kevin Tanady, Ling-Ting Huang, and Ling Chao*, “Rupturing Giant Plasma Membrane Vesicles to Form Micron-sized Supported Cell Plasma Membranes with Native Transmembrane Proteins”, Scientific Reports, 2017, 7: 15139
  2. B Lin, S Tsao, Alex Chen, Shu-Kai Hu, Ling Chao, and PG Chao*, “Lipid rafts sense and direct electric field-induced migration”, Proceedings of the National Academy of Sciences(PNAS), 2017, 114 (32), 8568-8573
  3. Hsing-Ying Tung, Ting-Pi Sun, Ho-Yi Sun, Zhen-Yu Guan. Shu-Kai Hu, Ling Chao, and Hsien-Yeh Chen*, “Construction and control of 3D porous structure based on vapor deposition on sublimation solids”, Applied Materialstoday, 2017, Volume 7, 77-81
  4. Yoshihisa Kaizuka*, Tomoto Ura, Shaowei Lyu, Ling Chao, Joel Henzie, and Hidenobu Nakao, “Cytosolic Transport of Nanoparticles through Pressurized Plasma Membranes for Molecular Delivery and Amplification of Intracellular Fluorescence” Langmuir, 2016, 32 (50), pp 13534–13545 (IF: 4.3) (SCI)
  5. Ling-Ting Huang and Ling Chao*, “The flow patterning capability of localized natural convection”, Phys. Chem. Chem. Phys., 2016, 18, 25380-25387 (SCI, IF: 4.45)
  6. Shu-Kai Hu, Ling-Ting Huang and Ling Chao*, “Membrane species mobility under in-lipid-membrane forced convection”, Soft Matter, 2016, 12, 6954-6963 (SCI, IF: 3.8)
  7. Chung-Ta Han and Ling Chao*, “Using a Patterned Grating Structure to Create Lipid Bilayer Platforms Insensitive to Air Bubbles”, Lab on a chip, 2015, 15(1), 86-93 (IF: 6.0) (SCI, EI) (featured on the front cover page of issue 1, 2015 and selected as a hot article in 2014 in Lab on a Chip, top 10% journal in biochemical research method category, SCI)
  8. Po-Yu Peng, Po-Chieh Chiang, and Ling Chao*, “Mobile Lipid Bilayers on Gold Surfaces through Structure-Induced Lipid Vesicle Rupture”, Langmuir, 2015, 31(13), 3904-3911 (IF: 4.3) (SCI, EI)
  9. Cheng-yu Kuan, Po-Yu Peng, and Ling Chao*, “運用延伸DLVO理論來預測能將支撐式脂質雙層膜形成於非傳統基材之實驗條件” 化工,2015, 62卷1期,103-117
  10. Shu-Kai Hu, Ya-Ming Chen and Ling Chao*, “Phase segregation of polymerizable lipids to construct filters for separating lipid-membrane-embedded species”, Biomicrofluidics, 2014, 8, 052005 (IF: 3.77) (SCI, EI)
  11. Po-Yu Peng, Po-Chieh Chiang, and Ling Chao*, “Controllable Occurrence of Free-Standing Lipid Membranes on Nanograting Structured Supports”, ACS Appl. Mater. Interfaces, 2014, 6 (15), 12261 (IF: 5.9) (SCI, EI)
  12. Chung-Ta Han and Ling Chao*, “Creating Air-Stable Supported Lipid Bilayers by Physical Confinement Induced by Phospholipase A2”, ACS Appl. Mater. Interfaces, 2014, 6 (9), 6378 (IF: 5.9) (SCI, EI)
  13. Yu-Ming Tu, Ling Chao*, “仿細胞膜平台的發展及應用” 化工,2014, 61卷1期, 59-72頁
  14. Charng-yu Lin, Ling Chao*, “Tunable Nucleation Time of Functional Sphingomyelinase-Lipid Features Studied by Membrane Array Statistic Tool”, Langmuir (2013), 29(42), 13008 (IF:4.3) (SCI, EI)
  15. Ling Chao, Mark Richards, C.-Y. Hsia, and Susan Daniel, “Separating and Sorting Membrane-bound Species Based on Chemical Affinity for Lipid Rafts”, Analytical Chemistry, 2013, 85, 6696 (IF: 5.7) (SCI, EI)
  16. Shu-Kai Hu, Sheng-Wen Hsiao, Hsun-Yen Mao, Ya-Ming Chen, Yung Chang, Ling Chao*, “Using Crosslinkable Diacetylene Phospholipids to Construct Two-dimensional Packed Beds in Supported Lipid Bilayer Separation Platforms”, Sci. Technol. Adv. Mater. ,2013, 14, 044408 (IF:3.75) (SCI, EI)