Hsien-Yeh Chen Professor

Index
Hsien-Yeh Chen Professor
陳賢燁 教授
phone:(02)3366-9476
fax:(02)2362-3040
email: hsychen@ntu.edu.tw
office:Tseng Jiang Hall(N)N410
Lab Info

Biointerface Engineering Lab

Tseng Jiang Hall(N)N407
(02)3366-1454
  • Education Background

B.S. Ch.E. National Taiwan University 1999
M.S. Ch.E. University of Michigan 2004
Ph.D. Ch.E. University of Michigan 2008

  • Research Topic

Biointerface Engineering
Latest advancements in biomaterials aim to control biological responses. The critical criteria for designing biointerfaces include controlled properties of biomolecules, non-fouling, compatibility with microfabrication, accessible within microgeometries, applicability on 3-D objects, defined microstructures, cell/surface responses, biodegradability, and the ability to create surface gradient. Our group has focused on engineering of biointerface by using vapor-based reactive polymers. Recent works include: 1. Biomimetic Surface Modifications; 2. Biomolecular Engineering and Surface Bioconjugate Chemistries; 3. Biomedical Coating Applications.

  • Recent Research Topic
  • Honor
  1. 指導學生蘇巧慈、陳勇智同學參加2013年生物醫學工程科技研討會暨國科會醫學工程學門成果發表會榮獲論文海報獎項
  2. 指導學生吳軍霆同學參加2014年中華民國高分子學會年會海報展示競賽榮獲優勝獎
  3. 多功能生物界面的研究成果刊登於國際期刊“Advanced Functional Materials”並且榮獲該期刊登於該雜誌內頁封面
  4. 抗菌生醫鍍膜的研究成果刊登於國際期刊“Journal of Materials Chemistry B”並且榮獲該期刊登於該雜誌封底封面
  5. 抗刮耐磨之生醫鍍膜技術的研究成果刊登於國際期刊“Advanced Materials Interfaces”並且榮獲該期刊登於該雜誌內頁封面
  6. 與謝之真教授合作開發全球首創的新型人工水晶體登上美國化學學會知名材料期刊《Chemistry of Materials》
  7. Enhanced Bone Morphogenic Property of Parylene-C 研究成果刊登於國際期刊”Biomaterials Science” (RSC)並且榮獲該期刊登於該雜誌內頁封面
  8. 榮獲2015年科技部-優秀年輕學者研究計畫獎助 (2015-2018)
  9. 指導學生官振禹同學參加2016年中華民國高分子學會年會,獲得口頭競賽佳作
  10. 指導學生官振禹同學參加2016年中華民國界面科學學會年會,獲得海報競賽佳作獎
  11. 指導學生官振禹同學參加2016年中國材料科學學會年會,獲得海報論文優等獎
  12. 擔任“Beilstein Journal of Nanotechnology, Coatings”, Guest Editor (2016/08 – 2017/10)
  13. 指導學生蔡亞庭及謝洪斌同學以「可調控光學特性及生物功能之人工水晶體」榮獲第13屆國家新創獎
  14. 榮獲2017年李長榮福聚教育基金會-傑出教授獎
  15. 榮獲2017年科技部-吳大猷先生紀念獎
  16. 指導學生陳詩婷同學參加2017年中國民國界面科學學會年會,獲得口頭競賽佳作獎
  17. 指導學生官振禹同學參加2017年中國民國界面科學學會年會,獲得口頭競賽優勝獎
  18. 指導學生官振禹同學參加2017年中國民國高分子學會年會,獲得口頭競賽佳作獎
  19. 指導吳治宇研究員參加2017年幾丁質幾丁聚醣暨生物材料研討會,獲得壁報展示第一名
  20. 指導學生邱亞茹同學參加2018年功能性材料研討會,獲得海報論文佳作獎
  21. 指導學生官振禹同學參加2018年功能性材料研討會,獲得英文口頭競賽第三名
  22. 指導學生何翠蘋同學參加2018年中華民國界面科學學會年會暨科技部計畫成果發表會,獲得海報競賽佳作獎
  23. 榮獲瑞典2018 International Association of Advanced Materials (IAAM) Scientist Award
  24. 擔任國際期刊 “Frontiers in Chemistry”, Guest Editor (2018/01 -迄今)
  1. Z. Y. Guan, C. W. Huang, M. C. Huang, C. Y. Wu, H. Y. Liu, S. T. Ding and H. Y. Chen, “Controlling multi-function of biomaterials interfaces based on multiple and competing adsorption of functional proteins”, Colloids and Surfaces B-Biointerfaces, 149, 130-137, 2017(Jan), (SCI,EI)
  2. P. R. Chen, T. C. Wang, S. T. Chen, H. Y. Chen and W. B. Tsai, “Development of Antifouling Hyperbranched Polyglycerol Layers on Hydroxyl Poly-p-xylylene Coatings”, Langmuir, 33(51), 14657-14662, 2017(Dec), (SCI,EI)
  3. H. Y. Chen, “Micro- and nano-surface structures based on vapor-deposited polymers”, Beilstein Journal of Nanotechnology, 8, 1366-1374, 2017(Jul)
  4. C. Y. Wu, C. W. Chang, R. H. Yuan, Y. C. Chiang, J. T. Chen, D. Y. Kang and H. Y. Chen, “Multifunctional nanoparticles with controllable dimensions and tripled orthogonal reactivity”, Nanoscale, 9(39), 14787-14791, 2017(Oct), (SCI,EI)
  5. R. H. Yuan, C. Y. Wu, H. Y. Tung, H. P. Hsieh, J. Li, Y. C. Chiang and H. Y. Chen, “Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface”, Macromolecular Bioscience, 17(4), 1600322, 2017(Apr)
  6. Z. Y. Guan, C. Y. Wu and H. Y. Chen, “Stepwise and Programmable Cell Differentiation Pathways of Controlled Functional Biointerfaces”, Acs Biomaterials Science & Engineering, 3(8), 1815-1821, 2017(Aug)
  7. C. Y. Wu, H. Y. Liu, C. W. Huang, S. Y. Yeh, N. C. Cheng, S. T. Ding and H. Y. Chen, “Synergistically Controlled Stemness and Multilineage Differentiation Capacity of Stem Cells on Multifunctional Biointerfaces”, Advanced Materials Interfaces, 4(11), 1700243, 2017(Jun)
  8. Y. T. Tsai, C. Y. Wu, Z. Y. Guan, H. Y. Sun, N. C. Cheng, S. Y. Yeh and H. Y. Chen, “Topologically Controlled Cell Differentiation Based on Vapor-Deposited Polymer Coatings”, Langmuir, 33(36), 8943-8949, 2017(Sep), (SCI,EI)
  9. C. W. Chang, Z. Y. Guan, M. Y. Kan, L. W. Lee, H. Y. Chen and D. Y. Kang, “Vapor-phase synthesis of poly(p-xylylene) membranes for gas separations”, Journal of Membrane Science, 539, 101-107, 2017(Oct), (SCI,EI)
  10. S. T. Chen, C. Y. Wu and H. Y. Chen, “Enhanced Growth Activities of Stem Cell Spheroids Based on a Durable and Chemically Defined Surface Modification Coating”, Acs Applied Materials & Interfaces, 10(38), 31882-31891, 2018(Sep), (SCI,EI)
  11. C. Y. Wu, H. P. Hsieh, S. T. Chen, T. Y. Liu and H. Y. Chen, “Fabrication of Functional Polymer Structures through Bottom-Up Selective Vapor Deposition from Bottom-Up Conductive Templates”, Langmuir, 34(15), 4651-4657, 2018(Apr), (SCI,EI)
  12. Z. Y. Guan, Y. K. Chen, C. Y. Wu, S. C. Wu, J. S. Yu and H. Y. Chen, “Surface modification: activation and deactivation of osteogenic differentiation based on detachable growth factor protein”, Journal of Materials Chemistry B, 6(2), 236-240, 2018(Jan), (SCI,EI)
  13. H. Y. Tung, Z. Y. Guan, T. Y. Liu and H. Y. Chen, “Vapor sublimation and deposition to build porous particles and composites”, Nature Communications, 9, 2018(Jul), (SCI)
  14. I. N. Ahmed, R. Chang, M. C. Keng, H. W. Chien, H. Y. Chen and W. B. Tsai, “Immobilization of functional polymers on poly(4-benzoyl-pxylylene-co-p-xylylene) films via photochemical conjugation for modulation of cell adhesion”, Colloids and Surfaces B-Biointerfaces, 174, 360-366, 2019(Feb), (SCI,EI)
  15. H. Y. Chen, T. Hayashi, M. Koenig and J. J. Lai, “Editorial: Polymer Surface Chemistry: Biomolecular Engineering and Biointerfaces”, Frontiers in Chemistry, 7, 2, 2019(Apr), (SCI)
  16. Y. C. Chiang, C. P. Ho, Y. L. Wang, P. C. Chen, P. Y. Wang and H. Y. Chen, “Vapor-Deposited Reactive Coating with Chemically and Topographically Erasable Properties”, Polymers, 11(10), 10, 2019(Oct), (SCI,EI)
  17. Z. Y. Guan, C. Y. Wu, T. Y. Chen, S. T. Huang, Y. C. Chiang and H. Y. Chen, “Clickable and Photo-Erasable Surface Functionalities by Using Vapor-Deposited Polymer Coatings”, Acs Biomaterials Science & Engineering, 5(4), 1753-1761, 2019(Apr), (SCI,EI)
  18. Y. T. Hsu, C. Y. Wu, Z. Y. Guan, H. Y. Sun, C. Mei, W. C. Chen, N. C. Cheng, J. S. Yu and H. Y. Chen, “Characterization of Mechanical Stability and Immunological Compatibility for Functionalized Modification Interfaces”, Scientific Reports, 9, 11, 2019(May), (SCI)
  19. K. C. Tang, K. C. Yang, C. W. Lin, Y. K. Chen, T. Y. Lu, H. Y. Chen, N. C. Cheng and J. S. Yu, “Human Adipose-Derived Stem Cell Secreted Extracellular Matrix Incorporated into Electrospun Poly(Lactic-co-Glycolic Acid) Nanofibrous Dressing for Enhancing Wound Healing”, Polymers, 11(10), 13, 2019(Oct), (SCI,EI)
  20. C. Y. Wu, Z. Y. Guan, P. C. Lin, S. T. Chen, P. K. Lin, P. C. Chen, P. H. G. Chao and H. Y. Chen, “Defined cell adhesion for silicon-based implant materials by using vapor-deposited functional coatings”, Colloids and Surfaces B-Biointerfaces, 175, 545-553, 2019(Mar), (SCI,EI)