Hsien-Yeh Chen Professor

Hsien-Yeh Chen Professor
陳賢燁 教授
email: hsychen@ntu.edu.tw
office:Tseng Jiang Hall(N)N410
Lab Info

Biointerface Engineering Lab

Tseng Jiang Hall(N)N407
  • Education Background

B.S. Ch.E. National Taiwan University 1999
M.S. Ch.E. University of Michigan 2004
Ph.D. Ch.E. University of Michigan 2008

  • Research Topic

Biointerface Engineering
Latest advancements in biomaterials aim to control biological responses. The critical criteria for designing biointerfaces include controlled properties of biomolecules, non-fouling, compatibility with microfabrication, accessible within microgeometries, applicability on 3-D objects, defined microstructures, cell/surface responses, biodegradability, and the ability to create surface gradient. Our group has focused on engineering of biointerface by using vapor-based reactive polymers. Recent works include: 1. Biomimetic Surface Modifications; 2. Biomolecular Engineering and Surface Bioconjugate Chemistries; 3. Biomedical Coating Applications.

  • Recent Research Topic
  • Honor
  1. 指導學生蘇巧慈、陳勇智同學參加2013年生物醫學工程科技研討會暨國科會醫學工程學門成果發表會榮獲論文海報獎項
  2. 指導學生吳軍霆同學參加2014年中華民國高分子學會年會海報展示競賽榮獲優勝獎
  3. 多功能生物界面的研究成果刊登於國際期刊”Advanced Functional Materials”並且榮獲該期刊登於該雜誌內頁封面.
  4. 抗菌生醫鍍膜的研究成果刊登於國際期刊”Journal of Materials Chemistry B”並且榮獲該期刊登於該雜誌封底封面.
  5. 抗刮耐磨之生醫鍍膜技術的研究成果刊登於國際期刊”Advanced Materials Interfaces”並且榮獲該期刊登於該雜誌內頁封面.
  6. 與謝之真教授合作開發全球首創的新型人工水晶體 登上美國化學學會知名材料期刊《Chemistry of Materials》
  7. Enhanced Bone Morphogenic Property of Parylene-C 研究成果刊登於國際期刊”Biomaterials Science” (RSC)並且榮獲該期刊登於該雜誌內頁封面
  8. 指導學生官振禹同學參加2016年中華民國高分子學會年會,獲得口頭競賽佳作
  9. 指導學生官振禹同學參加2016年中華民國界面科學學會年會,獲得海報競賽佳作獎
  10. 指導學生官振禹同學參加2016年中國材料科學學會年會,獲得海報論文優等獎
  11. 2015第13屆國家新創獎-「可調控光學特性及生物功能之人工水晶體」
  12. 2016科技部-吳大猷先生紀念獎
  13. 2016李長榮福聚教育基金會-傑出教授獎
  1. Yung-Chih Chen, Ting-Pi Sun, Chiao-Tzu Su, Jyun-Ting Wu, Chih-Yeh Lin, Jiashing Yu, Chao-Wei Huang, Chia-Jie Chen, and Hsien-Yeh Chen* “Sustained Immobilization of Growth Factor Proteins Based on Functionalized Parylenes,” ACS Applied Materials & Interfaces, 6, 21906−21910 (2014).
  2. Zhen-Yu Guan; Chih-Yu Wu; Yi-Jye Li; Hsien-Yeh Chen* ACS Applied Materials & Interfaces, 7, 14431 (2015).
  3. Jyun-Ting Wu; Ting-Pi Sun; Chao-Wei Huang; Chiao-Tzu Su; Chih-Yu Wu; Shu-Yun Yeh; Deng-Kai Yang; Lin-Chi Chen; Shih-Torng Ding; Hsien-Yeh Chen* Biomaterials Science 2015, 3, 1266 (2015).
  4. Jyun-Ting Wu; Chih-Yu Wu; Shih-Kang Fan; Chih-Chen Hsieh; Yu-Chih Hou; Hsien-Yeh Chen* Chemistry of Materials, 27, 7028 (2015).
  5. Ruei-Hung Yuan; Yi-Jye Li; Ho-Yi Sun; Chih-Yu Wu; Zhen-Yu Guan; Hsin-Ying Ho; Cheng-Yuan Fang; Hsien-Yeh Chen* Colloids and Surfaces B: Biointerfaces, 139, 259 (2015).
  6. Hsiu-Wen Chien, Ming-Chun Keng, Hsien-Yeh Chen*, Sheng-Tung Huang and Wei-Bor Tsai. “Conjugation of mono-sulfobetaine to alkyne-PPX films via click reaction to reduce cell adhesion”, Biomaterials and Biomechanics in Bioengineering, 3, 59-69 (2015)
  7. Ting-Pi Sun, Ching-Heng Tai, Jyun-Ting Wu, Chih-Yu Wu, Wei-Chieh Liang and Hsien-Yeh Chen*. “Multifaceted and route-controlled “click” reactions based on vapor-deposited coatings”, Biomaterials Science, 4, 265–271 (2016). (SCI, EI)
  8. Zhen-Yu Guan, Chih-Yu Wu, Jyun-Ting Wu, Ching-Heng Tai, Jiashing Yu and Hsien-Yeh Chen*. “Multifunctional and Continuous Gradients of Biointerfaces Based on Dual Reverse Click Reactions”, ACS Applied Materials & Interfaces, 8, 13812-13818 (2016).
  9. Chih-Yu Wu, Chao-Wei Huang, Zhen-Yu Guan, Jyun-Ting Wu, Shu-Yun Yeh, Chiao-Tzu Su, Chih-Hao Chang, Shih-Torng Ding and Hsien-Yeh Chen*. “Vapor-based coatings for antibacterial and osteogenic functionalization and the immunological compatibility”, Materials Science and Engineering C, 69, 283-291 (2016).
  10. Chih-Yu Wu, Ho-Yi Sun, Wei-Chieh Liang, Hung-Lun Hsu, Hsin-Ying Ho, Yu-Ming Chen and Hsien-Yeh Chen*. “Electrically charged selectivity of poly-para-xylylene deposition”, Chemical Communications, 52, 3022-3025 (2016).
  11. Ya-Ting Tsai, Chao-Wei Huang, Hui-Yu Liu, Mei-Ching Huang, Ting-Pi Sun, Wen-Chien Chen,* Chih-Yu Wu, Shih-Torng Ding and Hsien-Yeh Chen*. “Enhanced Bone Morphogenic Property of Parylene-C”, Biomaterials Science, 4, 1754-1760 (2016).
  12. Zhen-Yu Guan, Chao-Wei Huang, Mei-Ching Huang, Chih-Yu Wu, Hui-Yu Liu, Shih-Torng Ding and Hsien-Yeh Chen*. “Controlling Multi-Function of Biomaterials Interfaces Based on Multiple and Competing Adsorption of Functional Proteins”, Colloids and Surfaces B: Biointerfaces, 149, 130-137 (2017).
  13. Ruei-Hung Yuan, Chih-Yu Wu, Hsing-Ying Tung, Hung-Pin Hsieh, Yi-Jye Li, Yu-Chih Chiang and Hsien-Yeh Chen*. “Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface”, Macromolecular Bioscience, 17, 1600322-1600331 (2017)
  14. Hsing-Ying Tung, Ting-Pi Sun, Ho-Yi Sun, Zhen-Yu Guan, Shu-Kai Hu, Ling Chao, Hsien-Yeh Chen*. “Construction and Control of 3D Porous Structure Based on Vapor Deposition on Sublimation Solids” Applied Materials Today, 7, 77-81 (2017).
  15. Chih-Yu Wu, Hui-Yu Liu, Chao-Wei Huang, Shu-Yun Yeh, Nai-Chen Cheng, Shih-Torng Ding, Hsien-Yeh Chen*. “Synergistically Controlled Stemness and Multilineage Differentiation Capacity of Stem Cells on Multifunctional Biointerfaces”, Advanced Materials Interfaces, 1700243-1700253 (2017).
  16. Chih-Yu Wu, Chun-Wei Chang, Ruei-Hung Yuan, Yu-Chih Chiang, Jiun-Tai Chen, Dun-Yen Kang, Hsien-Yeh Chen*. “Multifunctional Nanoparticles with Controllable Dimensions and Tripled Orthogonal Reactivity”, Nanoscale, 9, 14787-14791 (2017).
  17. Ya-Ting Tsai, Chih-Yu Wu, Zhen-Yu Guan, Ho-Yi Sun, Nai-Chen Cheng, Shu- Yun Yeh, Hsien-Yeh Chen*. “Topologically Controlled Cell Differentiation Based on Vapor-Deposited Polymer Coatings”, Langmuir, 33, 8943-8949 (2017).
  18. Chao-Wen Chang, Zhen-Yu Guan, Ming-Yang Kan, Li-Wei Lee, Hsien-Yeh Chen*, Dun-Yen Kang*, “Vapor-Phase Synthesis of Poly(p-xylylene) Membranes for Gas Separations”, Journal of Membrane Science, 539, 101-107 (2017).
  19. Zhen-Yu Guan, Chih-Yu Wu, Hsien-Yeh Chen*. “Stepwise and Programmable Cell Differentiation Pathways of Controlled Functional Biointerfaces”, ACS Biomaterials Science & Engineering, 3, 1815-1821 (2017).
  20. Hsien-Yeh Chen*, “Micro- and Nano-Surface Structures Based on Vapor-Deposited Polymers”, Beilstein Journal of Nanotechnology, 8, 1366-1374 (2017).